No1, Be professional, use your full name in consistency, no nickname, no interchange between your maiden name and married name, no funny cute email address (Remember: this is job hunting not mate hunting), taking off those silly stuff from your face book.
No2, a round peg for a round hole
What if I am a round peg for a square hole?
Try to stretch, polish, or customize your resume by adding some relevant stuff to make it close to the job description. If time and money allows, get some technical certificates that the job requires.
No3 seeking help
Attending in a professional association, building your own network, getting free advice from WenxueCity Career forum (俺给职坦免费打广告泥)
No4, be flexible
Tells your potential employer, there is no problem for you to commute 60 miles per day to work. You can re-rent your apartment, relocate your house or even go abroad if it is what the job takes.
Desperate means in desperate situation.