您说"国内是瞎做", 可这是国内从美国引进的成熟技术, 我的Postdoc就是在U of Penn测病人高压氧后游离基

来源: 御用文人 2012-10-29 21:04:08 [] [旧帖] [给我悄悄话] 本文已被阅读: 0 次 (16448 bytes)

Pressure Sore – Decubitus Ulcer

Pressure sore

source: http://www.spinal-injury.net/pressure-sores-sci.htm

Pressure and bed sores ordecubitus ulcers are common complication in people confined to bed rest or wheelchair. The wound is caused by continuous pressure on the skin over bony prominence due to prolonged immobilization in one position reducing the normal blood flow.

People with spinal cord injury are especially prone to develop pressure sores due decreased or absent normal sympathetic nerve activity that is causing normal muscular contractions which are pumping blood throughthe vascular network called “muscle pump”. The major symptom is pain usually complicated by infection and inflammation. When infection spreads in deeper layers, a bone infection (osteomyelitis) can develop which can be fatal like in case of famous actor Christopher Reeve.

Pressure on the skin impairs circulation leading to ulcer and enhances bacterial overgrowth as well as inhibiting leukocyte function to eliminate bacteria and slowing synthesis of collagen (protein needed for wound to close). Inflammation causes toxic substances (ammonia and lactate) to accumulate in the tissue  leading to swelling, which is in turn further impairing blood supply and oxygen delivery. This is a vicious circle which further reduces oxygen supply and healing.

Hyperbaric oxygen directly affects the bacterial growth, improves white blood cell function, reduces swelling and inflammation and promotes collagen synthesis and fibroblast proliferation that are essential for new capillary growth and improved microcirculation (blood flow through capillaries).

Hyperbaric oxygen therapy for pressure sores is proven very successful and safe adjunctive treatment to daily wound dressing, administration of antibiotics and surgical debridment.

Hyperbaric oxygen (HBO) therapy for treatment of pressure sores

 

  1. HBO increases oxygen transport to wound area stopping further tissue damage
  2. HBO facilitates growth of new capillaries (angiogenesis) promoting the microcirculation
  3. HBO speeds up wound healing by reducing inflammation and swelling
  4. HBO relieves pain
  5. HBO reduces infection by eliminating bacteria directly and increasing capacity of white blood cell to fight infection
  6. HBO improves microcirculation and elimination of toxins in the blood
  7. HBO enhances the effect of some antibiotics
  8. HBO stimulates release of stem cells from the bone marrow
  9. HBO decreases blood viscosity and risk of thrombosis and stroke
  10. HBO improves lymphatic circulation
  11. HBO improves bone density and mineralization and speeds up bone healing
  12. HBO enhances peripheral nerve regeneration for improved sensitivity
  13. HBO prepares tissue and bone for grafting before surgery
  14. HBO speeds up healing after surgery and improves chances of graft survival

Electrical stimulation for treatment of pressure sores

 

Electrical stimulation is a non painful, non invasive effective therapy that uses electrical currents delivered through electrodes placed on the skin around the wound to promote the local blood flow and speed up wound healing and closure. At BaroMedical we use electrical stimulation in combination with hyperbaric oxygen therapy to achieve the best results in pain management, infection control and wound healing. Combined effect of two therapies used together is higher than each therapy used on its own. For your information we are attaching an extensive list of references and abstracts for use of electrical stimulation in wound healing.


Treatment protocol for hyperbaric oxygen therapy:

 

Medical hyperbaric oxygen sessions are two hours long at depth of 2.4 to 2.8 ATA of pure oxygen pressure.  At BaroMedical HBO sessions are given in mono-place chambers for better monitoring, comfort and safety.  Number of HBO sessions needed depend on the seriousness of the condition and can be determined upon evaluation of the microcirculation.  At BaroMedical, the screening of the clients and the progress of the therapy are monitored with most advanced equipment: Laser Doppler blood flow, tissue oxygen monitor and digital camera.


References:

 

  1. Blessey A, Eubanks A: Hyperbaric oxygen is an important adjunct therapy. Crit Care Nurse; 16(3):14-5, Jun 1996
  2. Dimitrijevich SD, Paranjape S, Wilson JR, Gracy RW, Mills JG: Effect of hyperbaric oxygen on human skin cells in culture and in human dermal and skin equivalents. Wound Repair Regen; 7(1): 53-64, Jan-Feb 1999
  3. Fabian TS, Kaufman HJ, Lett ED, Thomas JB, Rawl DK, Lewis PL, Summitt JB, Merryman JI, Schaeffer TD, Sargent LA, Burns RP: The evaluation of subatmospheric pressure and hyperbaric oxygen in ischemic full-thickness wound healing. Am Surg; 66(12): 1136-43, Dec 2000
  4. Halm M, Zearley C.Assessment and follow-up of problem wounds in the hyperbaric oxygen setting. Ostomy Wound Manage; 37 : 51-9, Nov-Dec199
  5. Kivisaari J, Niinikoski J. Effects of hyperbaric oxygenation and prolonged hypoxia on the healing of open wounds. Acta Chir Scand; 141(1): 14-9, 1975
  6. LaVan FB, Hunt TK: Oxygen and wound healing. Clin Plast Surg; 17(3):463-72, Review, Jul 1990
  7. Moon RE: Use of hyperbaric oxygen in the management of selected wounds. Adv Wound Care; 11(7): 332-4, Review, Nov-Dec 1998
  8. Oriani G: Chronic Hyperbaric Oxygen Therapy Indications, Handbook on Hyperbaric Medicine Springer 110-124,1996
  9. Quirinia A, Viidik A: The impact of ischemia on wound healing is increased in old age but can be countered by hyperbaric oxygen therapy. Mech Ageing Dev. 25; 91(2): 131-44, Oct 1996
  10. Quirinia A, Viidik A:The effect of hyperbaric oxygen on different phases of healing of ischaemic flap wounds and incisional wounds in skin. Br J Plast Surg; 48(8):583-9, Dec 1995
  11. Roth RN, Weiss LD: Hyperbaric oxygen and wound healing. Clin Dermatol;12(1):141-56 Review, Jan-Mar 1994
  12. Shafer MR: Use of hyperbaric oxygen as adjunct therapy to surgical debridement of complicated wounds. Semin Perioper Nurs; 2 (4):256-62, Oct 1993
  13. Shulman AG, Krohn HL: Influence of hyperbaric oxygen and multiple skin allografts on the healing of skin wounds. Surgery; 62 (6): 1051-8, Dec 1967
  14. Stone A. Hyperbaric oxygen treatment for wounds. Plast Reconstr Surg.1998 May; 101(6): 1738-9. Medicine1999; 14:213 –241
  15. Uhl E, Sirsjo A, Haapaniemi T, Nilsson G, Nylander G: Hyperbaric oxygen improves wound healing in normal and ischemic skin tissue. Plast Reconstr Surg; 93(4): 835-41, Apr 1994
  16. Young T: Hyperbaric oxygen therapy in wound management. Br J Nurs. 9; 4(14): 796,798-803, Review, 27 Jul –Aug 1995

所有跟帖: 

这就是研究和临床的差别。在临床上,没见过高压氧舱治疗褥疮的。估计没有 -betadine- 给 betadine 发送悄悄话 (66 bytes) () 10/29/2012 postreply 21:24:00

高压氧舱早已不是还停留在研究阶段, 而是经常用它治疗临床褥疮病人, 而且保险公司也付款... -御用文人- 给 御用文人 发送悄悄话 (2909 bytes) () 10/29/2012 postreply 22:30:48

你看你还拧这儿了。谁说保险不包高压氧舱了。而是不包它治褥疮。 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (38 bytes) () 10/30/2012 postreply 05:04:29

Non-healing wound 不一定都是褥疮啊? 不要混淆概念?你不在临床,有些事你也不知道。 -betadine- 给 betadine 发送悄悄话 (0 bytes) () 10/30/2012 postreply 05:22:11

回复:Non-healing wound 包括糖尿病溃疡。这个高压氧仓是包三期以上的。否则,那花费 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (135 bytes) () 10/30/2012 postreply 05:30:00

我跟的是御医生的贴。我可是support ninde -betadine- 给 betadine 发送悄悄话 (0 bytes) () 10/30/2012 postreply 05:43:43

我也是支持您的观点。进一步帮您解释一下。 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (0 bytes) () 10/30/2012 postreply 05:58:03

国内治疗一次顶多也就几百人民币。这个病人在国内,不一定非要用米国常规 -viewfinder- 给 viewfinder 发送悄悄话 viewfinder 的博客首页 (14 bytes) () 10/30/2012 postreply 06:54:21

关键是没必要啊。 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (248 bytes) () 10/30/2012 postreply 07:48:10

好奇,对于露骨头的那种深度褥疮,清创后下一步如何治的? -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (0 bytes) () 10/30/2012 postreply 08:12:31

我以前是用带血管蒂的肌皮辬转移修复。特别是足跟处,因为要耐磨。 -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 08:33:28

那就有骨髓炎了。一般有骨髓炎了。骨培养,抗生素。这时可用高压氧仓。 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (0 bytes) () 10/30/2012 postreply 08:37:39

不到骨髓炎程度,仅是骨头清晰可见而已。如何让肌肤再生愈合的? -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (49 bytes) () 10/30/2012 postreply 08:57:03

这可是临床中最常见的状况。 -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (0 bytes) () 10/30/2012 postreply 09:32:27

原则上见骨就应当用当骨髓炎治疗。还要根据病人情况综合考虑。必要时Hospice -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (0 bytes) () 10/30/2012 postreply 09:56:29

不对吧,骨髓炎治疗可以让肌肤再生愈合? 耗到这会儿人已没救了~ -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (0 bytes) () 10/30/2012 postreply 10:34:52

咱来个轻点的,2-3度如何让肌肤再生愈合? -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (0 bytes) () 10/30/2012 postreply 10:35:31

ConvanTec 就有很好的products 帮助肌肤重新长回来。当然护理还是最重要的,防患于未然。 -betadine- 给 betadine 发送悄悄话 (0 bytes) () 10/30/2012 postreply 15:21:37

临床上褥疮,长期卧床的重病人占大多数,自身肌肤再生能力已很弱,仅凭这帮助能有多大? -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (124 bytes) () 10/30/2012 postreply 17:07:28

当然要消除障碍了。清创本身重新启动自身再生机制。当然有些药物也可以帮助。 -richella- 给 richella 发送悄悄话 richella 的博客首页 (53 bytes) () 10/30/2012 postreply 12:27:41

这方法应付最多2度小面积且身体状况好的,更多情况,这行不通。呵呵 -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (0 bytes) () 10/30/2012 postreply 14:22:29

死心眼 -TBz- 给 TBz 发送悄悄话 TBz 的博客首页 (429 bytes) () 10/30/2012 postreply 17:46:33

呵呵,帮倒忙了~ -jck66- 给 jck66 发送悄悄话 jck66 的博客首页 (699 bytes) () 10/31/2012 postreply 04:39:41

我们附近的创口治疗中心打过高压氧舱治疗的广告。大约20年前,我在国内时的医院高压氧舱室就治疗褥疮。 -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 04:45:49

临床广泛应用了的话,还用打广告?non-healing wound 不一定都是褥疮。 -betadine- 给 betadine 发送悄悄话 (0 bytes) () 10/30/2012 postreply 05:17:44

Non-healing wound 不一定都是褥疮, 但是包括褥疮。这才是正解... -御用文人- 给 御用文人 发送悄悄话 (0 bytes) () 10/30/2012 postreply 07:24:17

通过读您的帖子我发现,美国的医疗水平比中国的落后50年 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (49 bytes) () 10/30/2012 postreply 07:54:20

小平弟弟不要跟御姐赌气啦^_^ -viewfinder- 给 viewfinder 发送悄悄话 viewfinder 的博客首页 (0 bytes) () 10/30/2012 postreply 07:59:02

啊?是位女士吗?那我得让着点。扫瑞! -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (0 bytes) () 10/30/2012 postreply 08:01:54

哈哈!不知道“御姐”这个词吗?百度去先 -viewfinder- 给 viewfinder 发送悄悄话 viewfinder 的博客首页 (0 bytes) () 10/30/2012 postreply 08:03:34

美国的乡村医院的医疗水平比中国的大医院落后这是事实吧。 -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 08:21:19

比什么?那里当然没有专科医生了。但是治疗上能做的,都中规中矩啊。 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (0 bytes) () 10/30/2012 postreply 08:41:21

比临床诊断水平。见过太多的误诊,不是因为仪器不允许,而是没有警惕。 -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 08:52:25

R医已经回答你了:"治疗上能做的,都中规中矩啊."你不拿 -闽姑- 给 闽姑 发送悄悄话 闽姑 的博客首页 (925 bytes) () 10/30/2012 postreply 09:38:49

嘿,美国乡村医院有高压氧舱吗?说国内有,错了吗?就这个技术来说可以用在褥疮治疗上错了吗?就事论事好吗? -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 09:43:03

美国乡村医院有高压氧舱。但全美国没有用它治疗褥疮的 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (0 bytes) () 10/30/2012 postreply 09:49:26

那是费用上的原因还是无效?纯技术,理论,不比条件。这是闽姑的意思吧? -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 09:54:10

上面回答了还是要说。根本每必要。属于过度治疗。 -Richella- 给 Richella 发送悄悄话 Richella 的博客首页 (207 bytes) () 10/30/2012 postreply 10:05:50

希望看到你的大作。你的flap 皮瓣可能是推移皮瓣,而我说的是带血管蒂肌皮瓣不是一回事。 -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (207 bytes) () 10/30/2012 postreply 10:49:42

我没有大作。说的flap就是vascular surgeon做的是带血管蒂肌皮瓣 -richella- 给 richella 发送悄悄话 richella 的博客首页 (195 bytes) () 10/30/2012 postreply 12:36:22

我能做这个手术,就一定掌握手术适应症。在感染没有控制前当然不会做咯。 -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 15:45:45

搞清楚谁要比?好吗? -薛成- 给 薛成 发送悄悄话 薛成 的博客首页 (0 bytes) () 10/30/2012 postreply 09:44:58

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