看了楼下疫苗3期临床试验的protocol。觉得Peter Doshi对结果的疑问有道理

来源: 2021-01-13 18:38:19 [] [博客] [旧帖] [给我悄悄话] 本文已被阅读: 次 (2969 bytes)

protocol是症状结合PCR测试:Combined with a positive PCR test result”、

https://bbs.wenxuecity.com/health/945713.html 

Peter Doshi质疑的是疑似情况:

https://blogs.bmj.com/bmj/2021/01/04/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data/

“Suspected covid-19”

All attention has focused on the dramatic efficacy results: Pfizer reported 170 PCR confirmed covid-19 cases, split 8 to 162 between vaccine and placebo groups. But these numbers were dwarfed by a category of disease called “suspected covid-19”—those with symptomatic covid-19 that were not PCR confirmed. According to FDA’s report on Pfizer’s vaccine, there were “3410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1594 occurred in the vaccine group vs. 1816 in the placebo group.

 

打疫苗有疑似症状的比placebo多15%。这结果本身是不是有些意外?由于PCR测试有高达30%的假阴性所以Peter Doshi对结果有疑问。要求更多细节和raw data。

所有跟帖: 

下面这个帖子的讨论你没有看吗? -TBz- 给 TBz 发送悄悄话 TBz 的博客首页 TBz 的个人群组 (194 bytes) () 01/13/2021 postreply 18:52:45

俺昨天贴了Doshi那个link。看了Pfizer等的procol后觉得Doshi怀疑有道理 -huntridge- 给 huntridge 发送悄悄话 huntridge 的博客首页 huntridge 的个人群组 (0 bytes) () 01/13/2021 postreply 19:14:42

看看这个视频 -TBz- 给 TBz 发送悄悄话 TBz 的博客首页 TBz 的个人群组 (188 bytes) () 01/13/2021 postreply 19:46:37

看了谢谢,俺也不认同19-29%有效率的说法所以也没提,但是认同需要更多细节和原始数据 (怎么排除假阴性?) -huntridge- 给 huntridge 发送悄悄话 huntridge 的博客首页 huntridge 的个人群组 (0 bytes) () 01/13/2021 postreply 20:22:34

UCSF江医生, 战斗在医务一线,也活跃在湾区跑群 -瞎走瞎拍- 给 瞎走瞎拍 发送悄悄话 瞎走瞎拍 的博客首页 瞎走瞎拍 的个人群组 (97 bytes) () 01/14/2021 postreply 12:09:57

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