看了楼下疫苗3期临床试验的protocol。觉得Peter Doshi对结果的疑问有道理

protocol是症状结合PCR测试：Combined with a positive PCR test result”、

https://bbs.wenxuecity.com/health/945713.html 

Peter Doshi质疑的是疑似情况：

https://blogs.bmj.com/bmj/2021/01/04/peter-doshi-pfizer-and-modernas-95-effective-vaccines-we-need-more-details-and-the-raw-data/

“Suspected covid-19”

All attention has focused on the dramatic efficacy results: Pfizer reported 170 PCR confirmed covid-19 cases, split 8 to 162 between vaccine and placebo groups. But these numbers were dwarfed by a category of disease called “suspected covid-19”—those with symptomatic covid-19 that were not PCR confirmed. According to FDA’s report on Pfizer’s vaccine, there were “3410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1594 occurred in the vaccine group vs. 1816 in the placebo group.”

 

打疫苗有疑似症状的比placebo多15%。这结果本身是不是有些意外？由于PCR测试有高达30%的假阴性所以Peter Doshi对结果有疑问。要求更多细节和raw data。