HPV传染这么广泛,传染途径大概也不是单一的吧。。。 其实有不少文献提示传染途径的多元性。。。
https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.13248
综述:33篇文章讨论高和低风险HPV非性传播的可能途径, 包括母婴传染,父婴传染,自身传染(从口腔到生殖器官或反向), 临床可能传染, 比如经阴道超声的probe很难消毒。。。
High-risk Oncogenic Human Papilloma Virus Infection of the Foreskin and Microbiology of Smegma in Prepubertal Boys. Urology 2015 Aug;86(2):368-372.
100 prepubertal healthy boys of median age of 5.7 years. "High-risk HPV was detected in 9 foreskins (9%). Positive samples showed are HPV16 (n = 3), 31 (n = 2), 39 (n = 3), and 51 (n = 1)."
100 男孩,(中位年龄 5.7岁)9% 小朋友检查看见高风险HPV.
High prevalence of human papillomavirus type 16 infection among children. PS Rice, C Mant, J Cason, JM Bible, P Muir, B Kell, JM Best. J Med Virol 2000 May;61(1):70-75.
In this study in London, 267 healthy children aged 3 to 11 were tested for the presence of HPV DNA in their mouths. HPV DNA was detected in only 45 (16.8%) by less-sensitive generic PCR, while HPV-16 specific nested PCR detected HPV-16 DNA in 138 (51.7%) of the samples. The prevalence of infection was similar regardless of age or sex. Also, in 6/53 (11.3%) of HPV-16 positive samples, reverse transcriptase PCR determined that there was active infection. (HPV-16 is the most common high-risk HPV type.)
Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: a six-year follow-up study. J Rautava, J Willberg, K Louvanto, L Wideman, K Syrjänen, S Grénman, S Syrjänen. PLoS One 2012;7(8):e42171. 324 pregnant women enrolled in the 3(rd) trimester. "The point prevalence of oral HPV varied from 15% to 24% during the 6-year follow-up. Altogether, 18 HPV genotypes were identified either as single or multiple-type oral infections. HPV16 was the most prevalent type at 9.7%-18.4%, followed by HPV18, HPV6, and multiple infections. Altogether, 74 women had persistent oral HPV infection determined as at least two consecutive samples positive with the same HPV genotype. HPV16 and HPV6 were the two most frequent types to persist (76% and 9%) for a mean of 18.6 and 20.2 months, respectively, followed by multiple infections (8%) for 18.3 months. An increased risk for persistent oral HPV infection with species 7/9 was associated with being seropositive for low-risk (LR)-HPV-types at baseline, whereas the use of oral contraceptives and a second pregnancy during follow-up were protective. Clinical oral lesions were detected in 17% of these women, one-third of whom had persistent oral HPV-infections."