御姐好,因为对DNA突变后的修复有问题,她们放疗好像会导致更多肿瘤,我上面写的令人糊涂了,改一下。。。
https://en.wikipedia.org/wiki/Ataxia_telangiectasia
Cancer and radiosensitivity
In the absence of the ATM protein, cell-cycle check-point regulation and programmed cell death in response to DSBs are defective. The result is genomic instability which can lead to the development of cancers.[25]
Irradiation and radiomimetic compounds induce DSBs which are unable to be repaired appropriately when ATM is absent. Consequently, such agents can prove especially cytotoxic to A-T cells and people with A-T.