Do not agree with you this time.

来源: Stonypoint 于 2011-09-18 21:11:16 [] [旧帖] [给我悄悄话] 阅读数 : (749 bytes)
回答: Disease of Gene, not Genetics, do you get it? 由 jaydad 于 2011-09-18 20:49:34

I used to admire your perfect Englsih, but this time you confused me.

Disease of gene? I do not hear this phrase often.

And genetics usually refers to 遗传学。I guess you meant 1-5% of cancers are hereditary.

Not all cancers are caused by gene mutations, for example, the cancers that we discussed in the last few days--those caused by HPV or other viruses, actually are not through somatic gene mutation. Rather, the viruses carry genes that can cause cells to proliferate. Again, look at HPV, the high risk viruses (HPV type 16, 18, 31, 33, etc) have genes (we call them oncogene) E6 and E7. These gene encode E6 and E7 proteins that inhibit tumor suppressor proteins p53 and pRb respectively, causing cells to grow.

所有跟帖： 

• broad definition of gene mutation -jaydad- ♂ 给 jaydad 发送悄悄话 jaydad 的博客首页 (689 bytes) () 09/18/2011 postreply 22:46:33

• In cancers caused by HPV, there are not cellular gene mutations -stonypoint- ♂ 给 stonypoint 发送悄悄话 (318 bytes) () 09/19/2011 postreply 13:57:37

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