Norovirus causes acute gastroenteritis in all age groups. Afebrile convulsion is an occasional neurologic complication in norovirus infection, but encephalitis is rare. We report the case of a previously healthy 15-month-old girl with norovirus encephalopathy who had a poor neurologic outcome. Norovirus (genogroup II) was detected in plasma and stool by real-time reverse transcription polymerase chain reaction, but the cerebrospinal fluid showed negative result for genome. Elevated concentrations of cerebrospinal fluid interleukin-6, interleukin-10, interferon-γ, and tumor necrosis factor-α were observed on the third day of illness. The encephalopathy in our patient may be related to hypercytokinemia rather than to direct viral invasion.
诺如病毒引起的脑病罕见,但是有报道
所有跟帖:
• 中文:部分患儿可伴有低热、呼吸道症状,偶有惊厥、脑病、脑炎 -dudaan- ♂ (0 bytes) () 01/30/2019 postreply 18:58:18
• 谢谢你找到这方面的病例报道 -妹吉大人- ♀ (177 bytes) () 01/30/2019 postreply 19:16:18
• 日本那个病例预后不好 -dudaan- ♂ (29 bytes) () 01/30/2019 postreply 19:19:35
• 事到如今也只能做好最坏的心理准备,但只要还有一丝康复的希望就要尽最大力气去争取。 -妹吉大人- ♀ (177 bytes) () 01/30/2019 postreply 19:41:25