http://www.thyroid.org/professionals/publications/news/04_08_11_fda_levothyroxine.html
注意其中重要结论:
According to bioequivalence data used to acquire FDA approval, one recently approved generic levothyroxine preparation (Sandoz Levothyroxine Sodium) is significantly more potent than the most widely used brand of levothyroxine (Synthroid®). Information from bioequivalence studies submitted to the FDA show that the new generic may be as much as one-eighth more potent (+12.5%) than the widely prescribed branded product.
你改用的Tirosint因该属于Levothyroxine Sodium那一类。
但你没有坚持服药也是问题,再加上更年期失眠,抑郁等其他因素导致你用药断断续续,影响药效。