Coley's 疫苗，实际上是最早和最原始的肿瘤免疫治疗方法。

    是Dr. Coley配制的一种含有已死的脓性链球菌和粘质沙雷氏菌的液体，用以替代他以往注入肿瘤的链球菌。这种液体后来被称做“Coley 毒素”，“Coley 疫苗”，“混合细菌毒素（ Mixed Bacterial Toxins ）” 或者“ Coley 液（ Coley Fluid ）”。一项1999年的研究显示，只要控制好“Coley 毒素”的用量，Coley 所使用的疗法是安全的，且具有和现在传统疗法一样的功效。现在美国主流肿瘤治疗领域已经不用这种方法。但是，并不意味着这种方法没有作用。

    现代肿瘤免疫治疗已经迅速发展。已有各类针对不同肿瘤的特异性和非特异性肿瘤免疫治疗方法用于临床试验或临床治疗。可以有针对性的寻求这些方法的治疗。 

       William Coley, M.D. was a leading oncologist in 19th Century America. From the turn of that century until the 1930's his innovative cancer vaccine was arguably the leading form of cancer treatment in the United States. It was government approved, and accepted by leading hospitals in the USA. 

     Coley's is a natural treatment for cancer. It uses natural chemical substances, those produced by microorganisms, as the basis for the medication. The natural chemicals are thought to be 1) toxic to cancer cells, 2) strong stimulators of the immune system, and 3) inducers of fever, a natural from of internal hyperthermia therapy. 

    Coley published his results and by the turn of the century 42 physicians from Europe and North America had reported cases of cancer that had been successfully treated with Coley Fluid. Coley Fluid became a mainstream cancer treatment and was successfully used in the treatment of most types of cancer. Until his death in 1936, Coley was the head of the bone tumor department at Memorial Hospital in New York City where he treated thousands of bone cancer patients with his fluid. In the United States the pharmaceutical company Parke Davis manufactured Coley Fluid until 1951.  

      Coley Fluid was a mainstream cancer therapy for many years, but its use particularly in the United States declined with the advent of chemotherapy. In 1962, an amendment to the Pure Food and Drug Act established the present system of FDA approval. The amendment included a "grandfather clause" that legalized drugs currently being marketed. Unfortunately, in 1962 no U.S. companies were marketing Coley Fluid so in spite of a 70-year history of safe and effective use, beginning in 1962 Coley Fluid was no longer an approved therapy in the United States

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• Dr.Coley 和 Coley Fluid Therapy 的故事 -堪诚- ♂ (11698 bytes) () 01/12/2012 postreply 12:09:06

• 有条件可以咨询做现代的免疫治疗。Coley Fluid 可能已经没公司做了。没有医生去培养细菌， -堪诚- ♂ (92 bytes) () 01/12/2012 postreply 15:34:55