The two lead articles in the recent issue of the medical journal "JAMA" show that the antioxidant vitamins C, E and the mineral selenium have no effect on preventing prostate cancer or other cancers in men.
In April 2008 a sophisticated analysis was conducted of all the randomized trials of antioxidant supplements involving adults. Together the trials included 232,606 participants. The analysis confirmed the previous year's "JAMA" report that the antioxidant supplements beta carotene, and vitamins A and E seem to increase risk of death.
As far back as 2000, large-scale clinical trials did not support — and even questioned — the use of vitamin E and beta carotene for protection against heart disease.
And in the 1990s, clinical studies looking at whether antioxidant supplements protected smokers against lung cancer found that beta carotene and vitamin A actually increased cancer risk.
Source - Mayo clinic
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