Paxlovid（nirmatrelvir 片剂；利托那韦片剂）是一种未经批准的产品，含有一种 SARS-CoV-2 主要蛋白酶（Mpro：也称为 3CLpro 或 nsp5 蛋白酶）抑制剂和一种 HIV-1 蛋白酶抑制剂和 CYP3A 抑制剂，根据紧急使用授权颁发 (EUA) 获得美国食品和药物管理局批准，用于治疗成人和儿科患者（12 岁及以上，体重至少 40 公斤）的轻度至中度冠状病毒病 2019 (COVID-19)，直接结果呈阳性 严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 病毒检测，以及进展为严重 COVID-19（包括住院或死亡）的高风险人群。
Paxlovid 的副作用是什么？
Paxlovid 的副作用包括：
口味的变化，
腹泻，
高血压（高血压），和
肌肉疼痛
严重的眼部症状，如视力突然下降、视力模糊、隧道视力、眼睛疼痛或肿胀，或在灯光周围看到光晕；
严重的心脏症状，例如快速、不规则或剧烈的心跳； 在你的胸膛飘动； 呼吸急促; 突然头晕，轻松，或昏倒；
剧烈头痛、意识模糊、言语不清、手臂或腿无力、行走困难、失去协调、感觉不稳、肌肉非常僵硬、高烧、大量出汗或颤抖。
Side Effects of Paxlovid (Nirmatrelvir Tablets and Ritonavir Tablets), Warnings, Uses (rxlist.com)
Paxlovid (nirmatrelvir tablets; ritonavir tablets) is an unapproved product that contains a SARS-CoV-2 main protease (Mpro: also referred to as 3CLpro or nsp5 protease) inhibitor and an HIV-1 protease inhibitor and CYP3A inhibitor issued under Emergency Use Authorization (EUA) by the U.S. Food and Drug Administration for the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death.
What Are Side Effects of Paxlovid?
Side effects of Paxlovid include:
- changes in taste,
- diarrhea,
- high blood pressure (hypertension), and
- muscle aches
Seek medical care or call 911 at once if you have the following serious side effects:
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
