ZT：糖尿病的干细胞疗法

啥叫I型糖尿病：https://dtc.ucsf.edu/zh-hans/糖尿病分型/1型糖尿病/了解1型糖尿病/什么是1型糖尿病/

1型糖尿病的发生，是因为生产胰岛素的细胞数量减少或功能不全, 这种细胞叫胰岛B细胞。B细胞损伤导致体内胰岛素分泌不足或消失。多数1型糖尿病患者有自身免疫基础，患者自身的免疫系统错误地攻击并破坏B细胞。因为胰岛素对维持生命至关重要，所以不足的胰岛素一定要补充。补充胰岛素可以用注射器或胰岛素泵来皮下注射。

 

除了胰岛素替代疗法，近年来干细胞移植技术给了“一糖”患者新的希望。

https://pubmed.ncbi.nlm.nih.gov/30362170/

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01793-6

https://www.ucihealth.org/blog/2020/03/diabetes-clinical-trial

The phase 1/2 study will determine whether the islet cell replacement therapy, a device called PEC-Direct, is safe and can provide blood glucose control in a manner similar to an artificial pancreas.

 

https://www.cryo-cell.com/treatments-and-research/diabetes

Brazilian Study Treating Type I Diabetes

A clinical trial conducted in Brazil comprising 21 adult patients with type 1 diabetes shows that a stem cell infusion may remedy the disease, at least for a number of years. Published during 2017 in the journal Frontiers in Immunology, the results showed that most patients became insulin-free for three and a half years and one patient did not have to use insulin for eight years. “We now understand stem cell transplants can succeed in treating diabetes for some,” said Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes, professor/founding chair of the Department of Diabetes Immunology and monitor of the clinical trial.

These positive outcomes were not the rule. For some patients, the stem cell transplant had little to no effect on their type 1 diabetes (T1D).

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Current Clinical Trials

A study out of Australia is recruiting children between the ages of 1 and 12 to see if a re-infusion of their own cord blood can help prevent type I diabetes in those who are at an enhanced risk.

The Institute of Metabolism and Endocrinology in China has a pair of studies looking at Treg cells from cord blood for diabetes.

A study on the Stem Cell Educator is currently in trial in China.

Another three different studies in China are using cord tissue stem cells for patients with diabetes.

A clinical trial in Vietnam is also looking at how cord tissue stem cells can treat the condition.

 

所有跟帖： 

• 夫子 -桃花好运- ♀ (261 bytes) () 08/20/2020 postreply 08:40:34

• 不行 -桃花好运- ♀ (213 bytes) () 08/20/2020 postreply 08:44:53

• 你家 -fuz- ♂ (381 bytes) () 08/20/2020 postreply 09:59:14

• 好的，谢谢。院子里多着呢。。 -桃花好运- ♀ (0 bytes) () 08/20/2020 postreply 10:09:15