这证明控制细胞信号传递路线来对付癌细胞的思路是对的。这的确是突破。

【zt】
Nexavar emerged from our collaboration with Bayer focused on identifying and developing inhibitors of inappropriate growth signaling in the RAS pathway. Nexavar is the first compound to target both the RAF/MEK/ERK signaling pathway to inhibit cell proliferation and the VEGFR-2/PDGFR-ß signaling cascade to inhibit tumor angiogenesis. RAF kinase is a specific enzyme in the RAS pathway. Mutations in the RAS gene occur in approximately 20 percent of all human cancers, including 90 percent of pancreatic cancer, 50 percent of colon cancer and 30 percent of non-small cell lung cancer. Recently, researchers found that a specific RAF kinase, BRAF, is mutated in two-thirds of melanomas and a low percentage of colorectal and other solid tumors. VEGFR-2 and PDGFR-ß are receptors of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), which play key roles in angiogenesis.

Nexavar is approved in the U.S. and E.U. for patients with advanced kidney cancer. In addition, due to positive interim results, we recently halted a Phase 3 study early in advanced liver cancer. Other pivotal trials in metastatic melanoma and in non-small cell lung cancer are being conducted. Nexavar is also being evaluated in single-agent Phase 2 clinical trials in lung, breast, and other cancers, along with several Phase 1/2 clinical trials studying the agent in combination with a range of standard chemotherapeutics and other anticancer agents.

所有跟帖： 

• 因为刚看了华阳复方，又看到这篇文章，所以有此想法 -出入自在- ♂ (314 bytes) () 06/06/2007 postreply 08:33:37

• You got to be kidding. This is science,华阳复方is vadoo. -weston- ♀ (448 bytes) () 06/06/2007 postreply 14:29:41

• typo: vadoo -> voodoo -weston- ♀ (0 bytes) () 06/06/2007 postreply 14:30:56

• Could you make some comments about this gov site? -出入自在- ♂ (50 bytes) () 06/06/2007 postreply 14:42:46

• 补充：科学态度 -出入自在- ♂ (744 bytes) () 06/06/2007 postreply 15:28:51

• 1) an analogy doesn't prove a thing. 2)when someone -weston- ♀ (307 bytes) () 06/06/2007 postreply 19:51:00

• 真正骗人的是，他故意混淆视听 -出入自在- ♂ (1526 bytes) () 06/06/2007 postreply 22:05:36

• 应为“真正骗人的是，他故意混淆视听” -出入自在- ♂ (0 bytes) () 06/06/2007 postreply 22:07:39

• 不知道为何“方*舟*子”一词不显示 -出入自在- ♂ (21 bytes) () 06/06/2007 postreply 22:11:47

• 美国食品与药品管理局=FDA 回复：真正骗人的是，他故意混淆视听 -celiacai- ♀ (207 bytes) () 06/07/2007 postreply 00:03:46

• 你是说没有FDA批准就可进行Phase III？ -出入自在- ♂ (360 bytes) () 06/07/2007 postreply 05:10:51

• 补充 -出入自在- ♂ (420 bytes) () 06/07/2007 postreply 12:04:28