JMA：服用复合维生素降低中老年男性患癌风险

作者：Michael Gaziano 来源：JAMA 发布时间：2012-11-1 15:56:57 选择字号：小 中 大

服用复合维生素降低中老年男性患癌风险     美国研究人员近日发表的研究报告显示，每日服用复合维生素可以降低50岁以上男性的患癌风险。   约5万名50岁以上男医生参加了这项受美国国家卫生研究院资助的研究，他们每天服用一片善存复合维生素或者安慰剂。超过10年的研究结束后，研究人员发现，服用维生素的人总体患癌率比服用安慰剂的人低8%，前者的癌症死亡率也显著下降。   相关研究报告当天发表在《美国医学会杂志》网络版上，同时也在美国癌症研究协会年会上公布。领导研究的布里格姆妇科医院副教授霍华德·塞索表示，他们目前还不清楚复合维生素中的哪种维生素或矿物质在抗癌方面发挥了作用，研究结果能否适用于女性及50岁以下男性也不清楚。布里格姆妇科医院是哈佛大学医学院的附属教学医院。   美国疾病控制和预防中心公布的数据显示，美国约半数成年人每天服用膳食补充剂，其中复合维生素最为常见。（来源：新华社 任海军）   Multivitamins in the Prevention of Cancer in Men  The Physicians' Health Study II Randomized Controlled Trial J. Michael Gaziano, MD, MPH; Howard D. Sesso, ScD, MPH; William G. Christen, ScD; Vadim Bubes, PhD; Joanne P. Smith, BA; Jean MacFadyen, BA; Miriam Schvartz, MD; JoAnn E. Manson, MD, DrPH; Robert J. Glynn, ScD; Julie E. Buring, ScD [+] Author Affiliations JAMA. 2012;308(18):1871-1880. doi:10.1001/jama.2012.14641.   Context  Multivitamin preparations are the most common dietary supplement, taken by at least one-third of all US adults. Observational studies have not provided evidence regarding associations of multivitamin use with total and site-specific cancer incidence or mortality. Objective  To determine whether long-term multivitamin supplementation decreases the risk of total and site-specific cancer events among men. Design, Setting, and Participants  A large-scale, randomized, double-blind, placebo-controlled trial (Physicians' Health Study II) of 14 641 male US physicians initially aged 50 years or older (mean [SD] age, 64.3 [9.2] years), including 1312 men with a history of cancer at randomization, enrolled in a common multivitamin study that began in 1997 with treatment and follow-up through June 1, 2011. Intervention  Daily multivitamin or placebo. Main Outcome Measures  Total cancer (excluding nonmelanoma skin cancer), with prostate, colorectal, and other site-specific cancers among the secondary end points. Results  During a median (interquartile range) follow-up of 11.2 (10.7-13.3) years, there were 2669 men with confirmed cancer, including 1373 cases of prostate cancer and 210 cases of colorectal cancer. Compared with placebo, men taking a daily multivitamin had a statistically significant reduction in the incidence of total cancer (multivitamin and placebo groups, 17.0 and 18.3 events, respectively, per 1000 person-years; hazard ratio [HR], 0.92; 95% CI, 0.86-0.998; P = .04). There was no significant effect of a daily multivitamin on prostate cancer (multivitamin and placebo groups, 9.1 and 9.2 events, respectively, per 1000 person-years; HR, 0.98; 95% CI, 0.88-1.09;P = .76), colorectal cancer (multivitamin and placebo groups, 1.2 and 1.4 events, respectively, per 1000 person-years; HR, 0.89; 95% CI, 0.68-1.17; P = .39), or other site-specific cancers. There was no significant difference in the risk of cancer mortality (multivitamin and placebo groups, 4.9 and 5.6 events, respectively, per 1000 person-years; HR, 0.88; 95% CI, 0.77-1.01; P = .07). Daily multivitamin use was associated with a reduction in total cancer among 1312 men with a baseline history of cancer (HR, 0.73; 95% CI, 0.56-0.96; P = .02), but this did not differ significantly from that among 13 329 men initially without cancer (HR, 0.94; 95% CI, 0.87-1.02; P = .15; P for interaction = .07). Conclusion  In this large prevention trial of male physicians, daily multivitamin supplementation modestly but significantly reduced the risk of total cancer. 原文链接：http://jama.jamanetwork.com/article.aspx?articleid=1380451

所有跟帖： 

• BMJ：大量补钙使女性死亡风险（主要是心脏病）加倍 -dudaan- ♂ (3963 bytes) () 02/14/2013 postreply 18:45:21

• 这个数据的解读需要谨慎 -华山97- ♂ (346 bytes) () 02/14/2013 postreply 22:30:31

• 谢谢老T和老杜。 -恶俗老狼- ♂ (174 bytes) () 02/14/2013 postreply 18:50:32

• 真理。 -薛成- ♂ (0 bytes) () 02/15/2013 postreply 00:35:17

• 中文翻译有一个明显错误 -华山97- ♂ (1002 bytes) () 02/14/2013 postreply 22:09:14

• 另外，这类研究所谓的“显著”作用，应该是统计学意义上的“显著”，就是说，两个对照 -slacker- ♂ (677 bytes) () 02/15/2013 postreply 11:22:49

• Co! 回复：另外，这类研究所谓的“显著”作用，应该是统计学意义上的“显著”，就是说，两个对照 -houtou72- ♂ (89 bytes) () 02/15/2013 postreply 17:10:30

• 每1000人，并不是只有1000人参与试验 -TBz- ♂ (0 bytes) () 02/15/2013 postreply 17:25:31

• 谢纠正 -TBz- ♂ (0 bytes) () 02/15/2013 postreply 23:15:55