CD4在2020年有不少文章。主要是癌症领域！没想到，COVID19逃过免疫吞噬的机制，竟然和癌症共通。
COVID19，莫名其妙地有了开启人体细胞的钥匙“SPIKE”
COVID19，对某些人（老人，高糖高血压。。。）可以躲过免疫吞噬，剧烈复制，最终太多了触发免疫风暴。杀死宿主。
COVID19的变异能力也是神级的，现在SPIKE可以稍微变化，导致针对SPIKE的防线漏洞百出。
真是病毒之神！
面对神一样的对手，明智的学者不会将鸡蛋都放在SPIKE一个篮子里，风险过高。如果最终出现完全的逃逸，怎么办？应该看看免疫过程的其他环节了！
CD47 is an immunoglobulin that is overexpressed on the surface of many types of cancer cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the escape of these cancer cells from macrophage-mediated phagocytosis. In recent years, CD47 has been shown to be highly expressed by various types of solid tumors and to be associated with poor patient prognosis in various types of cancer. A growing number of studies have since demonstrated that inhibiting the CD47-SIRPα signaling pathway promotes the adaptive immune response and enhances the phagocytosis of tumor cells by macrophages. Improved understanding in this field of research could lead to the development of novel and effective anti-tumor treatments that act through the inhibition of CD47 signaling in cancer cells. In this review, we describe the structure and function of CD47, provide an overview of studies that have aimed to inhibit CD47-dependent avoidance of macrophage-mediated phagocytosis by tumor cells, and assess the potential and challenges for targeting the CD47-SIRPα signaling pathway in anti-cancer therapy.
