综述:Ivermectin for Prevention and Treatment of COVID-19 Infection

来源: 2021-08-01 15:50:28 [] [博客] [旧帖] [给我悄悄话] 本文已被阅读: 次 (13322 bytes)
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介绍两篇综述性分析文章,让大家对印度防疫“神药”有所了解。

 

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

https://journals.lww.com/americantherapeutics/fulltext/2021/08000/ivermectin_for_prevention_and_treatment_of.7.aspx

Conclusions: 

Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.

 

 

另一篇回朔性分析文章,则有着不同的结论

https://pubmed.ncbi.nlm.nih.gov/34318930/

Authors' conclusions: Based on the current very low- to low-certainty evidence, we are uncertain about the efficacy and safety of ivermectin used to treat or prevent COVID-19. The completed studies are small and few are considered high quality. Several studies are underway that may produce clearer answers in review updates. Overall, the reliable evidence available does not support the use ivermectin for treatment or prevention of COVID-19 outside of well-designed randomized trials.

 

还有一篇综述也不推荐使用

https://www.news-medical.net/news/20210728/Systematic-review-explores-the-effects-of-ivermectin-in-preventing-and-treating-COVID-19.aspx

"The lack of good quality evidence on efficacy and safety of ivermectin arises from a study pool that consists mainly of small, insufficiently powered RCTs with overall limited quality regarding study design, conduct and reporting. Current evidence does not support using ivermectin for treating or preventing of COVID-19 unless they are part of well-designed randomized trials."

 

真正值得推敲的是这篇在二月份发表的临床研究。吃两次药,在之后的一个月里能减少近3/4的感染。很神奇啊。

Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247163

Results

Ivermectin prophylaxis was taken by 76 controls and 41 cases. Two-dose ivermectin prophylaxis (AOR 0.27, 95% CI, 0.15–0.51) was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Those involved in physical activity (AOR 3.06 95% CI, 1.18–7.93) for more than an hour/day were more likely to contract SARS-CoV-2 infection. Type of household, COVID duty, single-dose ivermectin prophylaxis, vitamin-C prophylaxis and hydroxychloroquine prophylaxis were not associated with SARS-CoV-2 infection.

Conclusion

Two-dose ivermectin prophylaxis at a dose of 300 μg/kg with a gap of 72 hours was associated with a 73% reduction of SARS-CoV-2 infection among healthcare workers for the following month. Chemoprophylaxis has relevance in the containment of pandemic.

 

接下来,印度疫情失控。无奈之下,一地方政府在五月十号决定发给居民“神药”。

https://www.firstpost.com/health/goa-prescribes-ivermectin-for-all-above-18-to-fight-covid-19-as-experts-flag-concern-all-you-need-to-know-9611751.html

 

二周后,当地政府声称病死例数真的降下来了。很神奇哟。

https://www.hindustantimes.com/cities/others/lower-mortality-goa-govt-defends-ivermectin-s-efficacy-against-covid19-101622188817860.html

In defence of its decision to administer Ivermectin, an anti-parasitic medicine for the use as prophylaxis, to Covid-19 patients, the Goa government, in a statement, has claimed that the mortality rate is much lower in patients who take the medicine than those who don’t.

 

 

 

 

FDA这样说的

https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19

Here’s What You Need to Know about Ivermectin

  • FDA has not approved ivermectin for use in treating or preventing COVID-19 in humans. Ivermectin tablets are approved at very specific doses for some parasitic worms, and there are topical (on the skin) formulations for head lice and skin conditions like rosacea. Ivermectin is not an anti-viral (a drug for treating viruses).
  • Taking large doses of this drug is dangerous and can cause serious harm. 
  • If you have a prescription for ivermectin for an FDA-approved use, get it from a legitimate source and take it exactly as prescribed. 
  • Never use medications intended for animals on yourself. Ivermectin preparations for animals are very different from those approved for humans. 

 

 

(EMA)欧盟也不赞同使用

EMA advises against use of ivermectin for the prevention or treatment of COVID-19 outside randomised clinical trials

https://www.ema.europa.eu/en/news/ema-advises-against-use-ivermectin-prevention-treatment-covid-19-outside-randomised-clinical-trials

 

 

所有跟帖: 

该药体内达到的浓度不足以抑制新冠病毒,差很多倍。 -吃与活- 给 吃与活 发送悄悄话 吃与活 的博客首页 吃与活 的个人群组 (467 bytes) () 08/01/2021 postreply 17:08:41

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