News: Pfizer Vaccine Protects Against the Most Severe Variants

Pfizer-BioNTech Vaccine Protects Against the Most Severe Outcomes of Some Virus Variants

https://www.nytimes.com/live/2021/05/05/world/covid-vaccine-coronavirus-cases#pfizer-vaccine-variants-covid

The Pfizer-BioNTech coronavirus vaccine is extraordinarily effective at protecting against severe disease caused by two dangerous variants, according to two studies published Wednesday.

The studies, which are based on the real-world use of the vaccine in Qatar and Israel, suggest that the vaccine can prevent the worst outcomes — including severe pneumonia and death — caused by B.1.1.7, the variant first identified in the U.K., and B.1.351, the variant first identified in South Africa.

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In multiple analyses, the researchers found that the vaccine was 87 to 89.5 percent effective at preventing infection with B.1.1.7 among people who were at least two weeks past their second shot. It was 72.1 to 75 percent effective at preventing infection with B.1.351 among those who had reached the two-week point.

The vaccine was highly effective at protecting against the worst outcomes. Overall, it was 97.4 percent effective at preventing severe, critical or fatal disease from any form of the coronavirus, and 100 percent effective at preventing severe, critical or fatal disease caused by B.1.1.7 or B.1.351.

 

 

 

ps 

original research paper

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

https://www.nejm.org/doi/10.1056/NEJMc2104974

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Effectiveness was estimated to be 87.0% (95% CI, 81.8 to 90.7) against the B.1.1.7 variant and 72.1% (95% CI, 66.4 to 76.8) against the B.1.351 variant, findings that confirm the results reported above.

The BNT162b2 vaccine was effective against infection and disease in the population of Qatar, despite the B.1.1.7 and B.1.351 variants being predominant within the country; however, vaccine effectiveness against the B.1.351 variant was approximately 20 percentage points lower than the effectiveness (>90%) reported in the clinical trial1 and in real-world conditions in Israel4 and the United States.5

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所有跟帖： 

• 读题目已经很开心啦，健康坛这位作者的转评我也是信赖。 -Sequoia_CA- ♀ (0 bytes) () 05/06/2021 postreply 06:45:49

• 非常感谢Fuz提供的信息和一直以来专业的解读！ -Lilac5- ♀ (0 bytes) () 05/06/2021 postreply 07:16:37

• 好像没有提到印度变种, B.1.167？ -听闻- ♀ (0 bytes) () 05/06/2021 postreply 07:55:49

• 这个是年初在南非做的临床试验。也许那时候印变还没传到 -fuz- ♂ (0 bytes) () 05/06/2021 postreply 08:36:34

• 谢谢分享 -Snow_summer- ♀ (0 bytes) () 05/06/2021 postreply 08:11:19

• 谢谢分享！！ -天天健康- ♀ (0 bytes) () 05/06/2021 postreply 16:59:56