一个报道,二重天地

本帖于 2021-01-28 07:06:39 时间, 由普通用户 fuz 编辑

晨起,迷迷糊糊,扫过一篇报道。咋看,觉得是好消息。闭眼一想,有点不对劲。再琢磨,毛骨悚然。

报道:https://mobile.reuters.com/article/amp/idUSKBN29W31

标题:Pfizer vaccine only slightly less effective against key South African mutations - study

从标题看,是个好消息: vaccine will still work against these new variants.

下面一段文中提到怎么得出这个结论的:用疫苗接种者身上诱导出来的抗体对病毒的中和滴定度来评估其有效性。

"Pfizer Inc and BioNTech's COVID-19 vaccine appeared to lose only a small bit of effectiveness against an engineered virus with three key mutations from the new coronavirus variant found in South Africa,according to a laboratory study conducted by the U.S. drugmaker.

The study by Pfizer and scientists from the University of Texas Medical Branch (UTMB), which has not yet been peer-reviewed, showed a less than two-fold reduction in antibody titer levels, indicating the vaccine would likely be effective in neutralizing a virus with the so-called E484K and N501Y mutations found in the South African variant.

The study here was conducted on blood taken from people who had received the vaccine. "

 

可扣细节,看到大坑了:"an engineered virus with three key mutations from the new coronavirus variant found in South Africa"

所用的病毒是按南非变种,人工合成的!!!

更糟的是,作者们滋滋不倦的还要接着合成

 "The scientists are currently engineering a virus with the full set of mutations and expect to have results from that in around two weeks, according to Pei-Yong Shi, an author of the study and a professor at UTMB."

.........

 "The study also showed even better results against several key mutations from the highly transmissible UK variant of the virus. Shi said they were also working on an engineered virus with the full set of mutations from that variant as well."

 

俺就搞不明白,这位'德大'(UTMB)的“Shi"到底咋想的呢?难道没看到武汉那个水深火热中的“石”?

还是想要证明其实验室比“石”厉害,有本事整出各种病毒?!

可万一,脑子一迷胡,手抖了一下,加错点啥,或按差了键,整出些更邪乎的新变种。

再不小心逛街时放个屁,嘣出来几个……………

这世界岂不更精彩。

 

这秧秧大国,咋就没人管这事呢?

 

请德大的朋友,转告那位Shi:

一念天堂 一念地狱 (the difference between heaven and hell lies in your way of thinking)

阿弥陀佛

所有跟帖: 

我也有一事不明 -dudaan- 给 dudaan 发送悄悄话 dudaan 的博客首页 (185 bytes) () 01/28/2021 postreply 05:40:00

科研要有经济支撑。近几十年来的倾向是:定制。所以,俺换了职业做数据库,可仍免不了被“按摩”。 -fuz- 给 fuz 发送悄悄话 fuz 的博客首页 (0 bytes) () 01/28/2021 postreply 05:47:49

看了你的贴,我怀疑哥伦比亚大学的“Ho"是不是也在搞人造病毒变异 -dudaan- 给 dudaan 发送悄悄话 dudaan 的博客首页 (0 bytes) () 01/28/2021 postreply 05:54:33

再生元的抗体的研发不需要活病毒和变异体 -xintian- 给 xintian 发送悄悄话 xintian 的博客首页 (211 bytes) () 01/28/2021 postreply 06:48:30

测定是否有效需要病毒 -dudaan- 给 dudaan 发送悄悄话 dudaan 的博客首页 (0 bytes) () 01/28/2021 postreply 07:12:57

实验室阶段的体外测试并不需要活病毒,临床试验是直接上人体给药,感染以后再分析病毒的类型 -xintian- 给 xintian 发送悄悄话 xintian 的博客首页 (0 bytes) () 01/28/2021 postreply 07:20:12

我非此业内人士,你看下面Fuz所说 -dudaan- 给 dudaan 发送悄悄话 dudaan 的博客首页 (0 bytes) () 01/28/2021 postreply 07:23:00

The engineered virus strains are for vaccine use. You need to en -twoboys_mom- 给 twoboys_mom 发送悄悄话 (116 bytes) () 01/28/2021 postreply 07:07:13

再仔细看看,好好想想。那些试验怎么做的 -fuz- 给 fuz 发送悄悄话 fuz 的博客首页 (0 bytes) () 01/28/2021 postreply 07:09:03

please specify -twoboys_mom- 给 twoboys_mom 发送悄悄话 (0 bytes) () 01/28/2021 postreply 07:09:30

这类抗体中和效价测定,要用培养的“活病毒”,和分离的抗血清。以往,病毒从病人身上分离、培养,不是合成的。方法见内 -fuz- 给 fuz 发送悄悄话 fuz 的博客首页 (133 bytes) () 01/28/2021 postreply 07:16:14

I don't see much difference. It's a very routine procedure. -twoboys_mom- 给 twoboys_mom 发送悄悄话 (0 bytes) () 01/28/2021 postreply 08:18:15

关键在“合成制造病毒”,会不会造出超级病毒。这属于监管程序。临床上测抗体中和,应该使用来自病人的毒株 -fuz- 给 fuz 发送悄悄话 fuz 的博客首页 (0 bytes) () 01/28/2021 postreply 08:44:27

I see your point. We are living in a risky world. Double sword. -twoboys_mom- 给 twoboys_mom 发送悄悄话 (0 bytes) () 01/28/2021 postreply 08:47:36

Pseudovirus,就是合成了一个有S蛋白但没其它成分的病毒,试验都是用假病毒做的,否则就需要P4实验室,美国也没几个 -朱头山- 给 朱头山 发送悄悄话 朱头山 的博客首页 (0 bytes) () 01/28/2021 postreply 09:00:44

文章开篇“ We engineered three SARS-CoV-2 viruses containing key spik -fuz- 给 fuz 发送悄悄话 fuz 的博客首页 (28946 bytes) () 01/28/2021 postreply 09:11:55

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