Original Investigation
Infectious Diseases
December 10, 2020
Risk Factors Associated With In-Hospital Mortality in a US National Sample of Patients With COVID-19
Ning Rosenthal, MD, MPH, PhD1; Zhun Cao, PhD1; Jake Gundrum, MS1; et alJim Sianis, PharmD, MBA1; Stella Safo, MD, MPH1
JAMA Netw Open. 2020;3(12):e2029058. doi:10.1001/jamanetworkopen.2020.29058
Key Points
Question What are the epidemiologic characteristics of patients with coronavirus disease 2019 (COVID-19) treated in US hospitals, and what risk factors are associated with mortality?
Findings In this cohort study of 64?781 patients with COVID-19 treated in 592 US hospitals during April and May 2020, the in-hospital mortality rate was 20.3% among inpatients, and severe complications were common. Receipt of statin, angiotensin-converting enzyme inhibitors, and calcium channel blockers were associated with decreased odds of mortality, but the combination use of hydroxychloroquine and azithromycin was associated with increased odds of mortality.