news: Covid-19 Likely in U.S. in Mid-December 2019

本帖于 2020-12-01 01:06:00 时间, 由普通用户 fuz 编辑

https://www.wwno.org/post/coronavirus-was-us-weeks-earlier-previously-known-study-says

https://www.npr.org/sections/coronavirus-live-updates/2020/12/01/940395651/coronavirus-was-in-u-s-weeks-earlier-than-previously-known-study-says 

https://www.wsj.com/amp/articles/covid-19-likely-in-u-s-in-mid-december-2019-cdc-scientists-report-11606782449

New analysis of blood donations finds virus was present on West Coast earlier than previously believed

The new coronavirus infected people in the U.S. in mid-December 2019, a few weeks before it was officially identified in China and about a month earlier than public health authorities found the first U.S. case, according to a government study published Monday.

The findings significantly strengthen evidence suggesting the virus was spreading around the world well before public health authorities and researchers became aware, upending initial thinking about how early and quickly it emerged.

Scientists at the U.S. Centers for Disease Control and Prevention found evidence of infection in 106 of 7,389 blood donations collected by the American Red Cross from residents in nine states across the U.S., according to the study published online in the journal Clinical Infectious Diseases.

.........

In analyzing the blood samples, the CDC scientists found antibodies in 39 samples from California, Oregon and Washington state collected between December 13 and December 16.

The findings suggest there were isolated cases of coronavirus infection on the U.S. West Coast in mid-December, the scientists wrote.

They also found 67 samples with antibodies in Massachusetts, Michigan, Wisconsin or Iowa, and Connecticut or Rhode Island collected between Dec. 30 and Jan. 17.

Those findings indicated that cases were more dispersed—yet still isolated—by early this year.

 

 

PS

The research article

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1785/6012472


Methods

To determine if SARS-CoV-2 reactive antibodies were present in sera prior to the first identified case in the U.S. on January 19, 2020, residual archived samples from 7,389 routine blood donations collected by the American Red Cross from December 13, 2019 to January 17, 2020, from donors resident in nine states (California, Connecticut, Iowa, Massachusetts, Michigan, Oregon, Rhode Island, Washington, and Wisconsin) were tested at CDC for anti-SARS-CoV-2 antibodies. Specimens reactive by pan-immunoglobulin (pan Ig) enzyme linked immunosorbent assay (ELISA) against the full spike protein were tested by IgG and IgM ELISAs, microneutralization test, Ortho total Ig S1 ELISA, and receptor binding domain / Ace2 blocking activity assay.

Results

Of the 7,389 samples, 106 were reactive by pan Ig. Of these 106 specimens, 90 were available for further testing. Eighty four of 90 had neutralizing activity, 1 had S1 binding activity, and 1 had receptor binding domain / Ace2 blocking activity >50%, suggesting the presence of anti-SARS-CoV-2-reactive antibodies. Donations with reactivity occurred in all nine states.

Conclusions

These findings suggest that SARS-CoV-2 may have been introduced into the United States prior to January 19, 2020.

 

所有跟帖: 

今后应该增加对“流感”病例的病毒分析 -dudaan- 给 dudaan 发送悄悄话 dudaan 的博客首页 (518 bytes) () 12/01/2020 postreply 04:53:15

possible, i was so sick in 12/2019 -hz82000- 给 hz82000 发送悄悄话 hz82000 的博客首页 (0 bytes) () 12/01/2020 postreply 06:23:16

上面两位网友有抗体吗? -日月茗- 给 日月茗 发送悄悄话 (0 bytes) () 12/01/2020 postreply 08:25:57

我没去测 -hz82000- 给 hz82000 发送悄悄话 hz82000 的博客首页 (0 bytes) () 12/01/2020 postreply 08:29:01

你家人那段时间有症状吗? -日月茗- 给 日月茗 发送悄悄话 (0 bytes) () 12/01/2020 postreply 08:34:22

有,sick,只有我用笔记录下来了,我们都没去看病 -hz82000- 给 hz82000 发送悄悄话 hz82000 的博客首页 (0 bytes) () 12/01/2020 postreply 09:05:05

我记得这事,我当时还说要你和家人分餐和分床。你当时症状和burpeejump医生的一样吗?有啥区别? -lawattaction- 给 lawattaction 发送悄悄话 (0 bytes) () 12/01/2020 postreply 10:09:00

那你们真该去测一下是否有抗体了,对以后要不要打疫苗、何时打疫苗,心里也有数 -日月茗- 给 日月茗 发送悄悄话 (0 bytes) () 12/01/2020 postreply 11:56:32

夫子说几个月后抗体就没了 -dudaan- 给 dudaan 发送悄悄话 dudaan 的博客首页 (0 bytes) () 12/01/2020 postreply 18:56:47

你讲过几次,我有印象,你们全家应该去测一下抗体 -qiu_yi- 给 qiu_yi 发送悄悄话 (0 bytes) () 12/01/2020 postreply 12:26:31

中国青年报马上借题发挥成比中国早,其实原文开篇特别指明中国最早病例追遡到12月1日。 -日月茗- 给 日月茗 发送悄悄话 (319 bytes) () 12/01/2020 postreply 08:32:57

有症状不能证明任何事,我朋友的妈妈,60多岁的,去年夏天在湖北死于肺炎,现在看来也挺可疑的,可是不能算科学根据。 -greennew- 给 greennew 发送悄悄话 (160 bytes) () 12/01/2020 postreply 08:50:30

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