谢谢。治疗过程较长，用了羟喹加锌等药。一顿乱挙，很难说哪一招起了关键作用。

杜编给了原英文文本的链接：

https://poseidon01.ssrn.com/delivery.php?ID=500081090119064071077113004126102005101045049046016042072027065122094088124084003005023096127020057022043123102082117011028090114061008054038081008095091073064083069014023083118094007024093098119081008017103001105080075002096104116068002124087103005096&EXT=pdf

其中摘要：

Her deterioration was therefore felt to be the result of cytokine storm. Tocilizumab – a humanized monoclonal antibody that inhibits ligand binding to the human interleukin-6 receptor (IL-6R) used for juvenile rheumatoid arthritis and used now experimentally for COVID-19 associated cytokine storm – was requested. However, strict hospital protocol prohibited the use of this drug outside of the ICU – and because her O2 % sat on high flow nasal O2 (6 liters) was still ≥ 90 (i.e. 91-92) - she did not meet criteria for ICU transfer.
She therefore agreed to begin over the counter (OTC) nicotinamide mononucleotide (NMN) with betaine and NaCl drunk in 400cc water known to lower IL-6. The BID dosage was timed in syn with the patient’s presumed diurnal circadian rhythm peaks while continuing the daily zinc sulfate (Table 1).

请注意上图中间一行，淋巴细胞绝对计数。第11日490；12日291；13日540。比较第13日和第12日的数值，得出结论：用NMN后淋巴细胞数增加，是转折点。

质疑：其它日子里的淋巴细胞检测值为什么缺失？

做为重病住院患者，每天必须做血分类计数，甚至不止一次。由此可见，此作者对数据做了筛选，结果推论不可信。

 

 

 

俺在三十年前从亊过线粒体呼吸吸链方面的研究，对这东东也有所了解。

口服，真没啥用；注射，可缓解心肌缺血性坏死。

近年来，把这东东吹成抗衰老神药，实在有点扯。

这东东，极不稳定，很难长期保存。不如吃点B3，可以吸收入人体内，进而合成NMN。

https://www.elysiumhealth.com/en-us/science-101/the-benefits-of-vitamin-b3

https://en.wikipedia.org/wiki/Nicotinamide_mononucleotide

 

 

 

这是是最近一篇关于NMN的综述性文章，讲了体内合成及其临床应用的潜力

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359187/

 

在小鼠，证明对老化有作用

https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(16)30495-8