为何不服用keppra？keppra 抑制钙离子进入神经细胞，抑制兴奋。Mg 拮抗，作用类似。

来源: 欲千北 于 2020-03-23 17:59:17 [] [博客] [旧帖] [给我悄悄话] 本文已被阅读： 次 (4791 bytes)
本文内容已被 [ 欲千北 ] 在 2020-03-23 18:00:53 编辑过。如有问题，请报告版主或论坛管理删除.

Mechanism of action[edit]

The exact mechanism by which levetiracetam acts to treat epilepsy is unknown. Levetiracetam does not exhibit pharmacologic actions similar to that of classical anticonvulsants. It does not inhibit voltage-dependent Na+ channels, does not affect GABAergic transmission, and does not bind to GABAergic or glutamatergic receptors.[30] However, the drug binds to SV2A,[31] a synaptic vesicle glycoprotein, and inhibits presynaptic calcium channels,[32] reducing neurotransmitter release and acting as a neuromodulator. This is believed to impede impulse conduction across synapses.[33]

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