病人目前的一般情况按ECOG打分为3-4分。具体见下表。
抗肿瘤治疗一般在患者ECOG 0-1 时进行。有时可以放宽到2。
可以用中药支持治疗,中西医结合会更好。有贫血的要输血,有粒细胞减少/缺乏的要用集落刺激因子,有水、电解质、酸碱失衡的要纠正,有抑郁的要抗抑郁治疗帮助恢复体力,有感染的要抗感染治疗等等。
等一般情况好转了,再考虑抗肿瘤治疗。这里是Drugs Approved for Non-Hodgkin Lymphoma。 应先考虑使用这些药物/方案,毕竟是临床试验证明有效的。pembrolizumab在血液肿瘤的疗效还不确定,在实体瘤也不是每种类型效果都好的。
Karnofsky Status | Karnofsky Grade | ECOG Grade | ECOG Status |
---|---|---|---|
Normal, no complaints | 100 | 0 | Fully active, able to carry on all pre-disease performance without restriction |
Able to carry on normal activities. Minor signs or symptoms of disease | 90 | 1 | Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work |
Normal activity with effort | 80 | 1 | Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work |
Care for self. Unable to carry on normal activity or to do active work | 70 | 2 | Ambulatory and capable of all selfcare but unable to carry out any work activities. Up and about more than 50% of waking hours |
Requires occasional assistance, but able to care for most of his needs | 60 | 2 | Ambulatory and capable of all selfcare but unable to carry out any work activities. Up and about more than 50% of waking hours |
Requires considerable assistance and frequent medical care | 50 | 3 | Capable of only limited selfcare, confined to bed or chair more than 50% of waking hours |
Disabled. Requires special care and assistance | 40 | 3 | Capable of only limited selfcare, confined to bed or chair more than 50% of waking hours |
Severly disabled. Hospitalisation indicated though death nonimminent | 30 | 4 | Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair |
Very sick. Hospitalisation necessary. Active supportive treatment necessary | 20 | 4 | Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair |
Moribund | 10 | 4 | Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair |
Dead | 0 | 5 | Dead |