今日文章：Statins can increase the risk of heart attacks

Statins were developed to lower cholesterol, but they also block a molecule needed to produce vitamin K, which prevents calcification of the arteries.

The author of the report, published in Expert Review of Clinical Pharmacology, says there is 'no evidence to support people taking statins', which opponents say also cause other health issues including skeletal weakness and muscle pain.

Professor Harumi Okuyama, of Nagoya City University, Japan, told the Sunday Express:'We have collected a wealth of information on cholesterol and statins from many published papers and find overwhelming evidence that these drugs accelerate hardening of the arteries and can cause, or worsen, heart failure.'

Similarly, Dr Peter Langsjoen, a heart specialist based in Texas who is co-author of the study, said: 'These drugs should never have been approved for use. The long-term effects are devastating.'

Read more: http://www.dailymail.co.uk/health/article-3392611/Statins-increase-risk-heart-attacks-no-evidence-support-patients-taking-warn-researchers.html#ixzz3wumPkgE1

 

 

日本的血脂干预试验显示，服药6年后总胆固醇在200-250 mg/dL时，其总体的死亡风险最低。

Figure 8. Japan Lipid Intervention Trial with a low dose of simvastatin. Those with total cholesterol (TC) levels of ≥220 mg/dl were treated with simvastatin for 6 years (n = 41,801, 35–70 years of age) 26. Matsuzaki M, Kita T, Mabuchi H, et al. Large scale cohort study of the relationship between serum cholesterol concentration and coronary events with low-dose simvastatin therapy in Japanese patients with hypercholesterolemia. Circ J 2002;66(12):1087-95•  The first large-scale intervention trial with simvastatin performed mostly by members of the Japan Atherosclerosis Society. This article is important in understanding how the results are inconsistent with their cholesterol guidelines and were skewed by their interpretations.

View all references.

来源：Expert Review of Clinical Pharmacology

http://www.tandfonline.com/doi/full/10.1586/17512433.2015.1011125

 

所有跟帖： 

• 兄台苦口婆心令人敬佩!可惜听者藐藐的多呢. -gtcharlie- ♂ (0 bytes) () 01/11/2016 postreply 02:49:37

• 妖魔化胆固醇的毒害，太久太广。 -益生菌- ♂ (0 bytes) () 01/11/2016 postreply 05:24:33

• 服药降胆固醇就相当于贿赂老师把成绩改好。体检报告结果虽然好看但是在欺骗自己。 -羽衣甘蓝- ♂ (0 bytes) () 01/11/2016 postreply 03:37:58

• 好比喻，但结果更不好看，更虚假。 -益生菌- ♂ (0 bytes) () 01/11/2016 postreply 05:22:34

• 药不治病，反而制造病！庆幸自己天生爱运动，又不馋肉，几乎没吃过什么药，至今很健康。 -lawattaction- ♀ (0 bytes) () 01/11/2016 postreply 12:46:39

• 我总胆固醇230，需要吃药吗？我正在积极锻炼，希望下次低点。 -我爱栀子花- ♀ (0 bytes) () 01/11/2016 postreply 05:36:05

• 最重要和有预测意义的是——总胆固醇(TC)与HDL-C的比值，即总胆固醇与回收中的胆固醇的比值。 -益生菌- ♂ (653 bytes) () 01/11/2016 postreply 06:06:45

• 谢谢！今年体检后算算。 -我爱栀子花- ♀ (0 bytes) () 01/11/2016 postreply 06:43:49

• 正好在平均值,还得继续锻炼... -桃花好运- ♀ (0 bytes) () 01/11/2016 postreply 09:03:22

• cholesterol fasting 4.75,HDL 2, cholesterol/HDL ratio is 2.4 这 -lawattaction- ♀ (0 bytes) () 01/11/2016 postreply 11:43:17

• 说实话我可是吃了很多鸡蛋，但我的胆固醇结果都很好，怎么解释？：韭菜炒鸡蛋，大葱炒鸡蛋，番茄炒鸡蛋，etc. -lawattaction- ♀ (0 bytes) () 01/11/2016 postreply 11:50:32

• 我以前解释过，膳食胆固醇是与硫酸根结合的，是水溶性的，很容易被心脏和大脑直接利用，而脂蛋白上的胆固醇不能。 -益生菌- ♂ (0 bytes) () 01/11/2016 postreply 12:16:11

• 谢谢！ 那鸡蛋是膳食胆固醇？什么是脂蛋白上的胆固醇？请举例。 -lawattaction- ♀ (0 bytes) () 01/11/2016 postreply 12:31:18

• 谢谢介绍这篇文章。待俺慢慢学习。。。 -御用文人- ♀ (0 bytes) () 01/11/2016 postreply 10:42:32

• 不谢。我在一年多前写过一篇帖子 ——降胆固醇药物之悖论，尽管未写上与心力衰竭的关系。 -益生菌- ♂ (0 bytes) () 01/11/2016 postreply 12:44:56