Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter
John L. Wallace & Rui Wang
AffiliationsCorresponding author
Nature Reviews Drug Discovery 14, 329–345 (2015) doi:10.1038/nrd4433
Published online 07 April 2015
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Abstract
Abstract? References? Author information
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials.
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Figures
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Cytosolic and mitochondrial production and functions of H2S.
Figure 1
The pathogenic roles of H2S at different stages of diabetes development.
Figure 2
Anti-inflammatory and cytoprotective targets of H2S.
Figure 3
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John L. Wallace & Rui Wang
AffiliationsCorresponding author
Nature Reviews Drug Discovery 14, 329–345 (2015) doi:10.1038/nrd4433
Published online 07 April 2015
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Abstract
Abstract? References? Author information
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule throughout the body, contributing to many physiological and pathological processes. In recent years, improved methods for measuring H2S levels and the availability of a wider range of H2S donors and more selective inhibitors of H2S synthesis have helped to more accurately identify the many biological effects of this highly reactive gaseous mediator. Animal studies of several H2S-releasing drugs have demonstrated considerable promise for the safe treatment of a wide range of disorders. Several such drugs are now in clinical trials.
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At a glance
Figures
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left
Cytosolic and mitochondrial production and functions of H2S.
Figure 1
The pathogenic roles of H2S at different stages of diabetes development.
Figure 2
Anti-inflammatory and cytoprotective targets of H2S.
Figure 3
right
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