查到一篇：5 mg finasteride/day 少量增加1.25-dihydroxyvitamin D（有活性的VD）

这可能是你血钙升高的原因.  测的（和吃的）25D是1，25D的前体，25D低不一定1，25D就低，而1，25D是有生物活性的。建议与医生讨论时提到这篇文献，问他是否该测1，25D。还是不要吃VD3

http://www.ncbi.nlm.nih.gov/pubmed/1283117

Clin Endocrinol (Oxf). 1992 Nov;37(5):432-6.

Prolonged treatment with finasteride (a 5 alpha-reductase inhibitor) does not affect bone density and metabolism.

Matzkin H¹, Chen J, Weisman Y, Goldray D, Pappas F, Jaccard N, Braf Z.

Author information

• ¹Department of Urology, Ichilov Hospital, Tel Aviv, Israel.

Abstract

OBJECTIVE:

Since it is not clear whether testosterone or dihydrotestosterone is the active hormone in bone metabolism, we wished to assess the effect of finasteride, a 5 alpha-reductase inhibitor, or vertebral bone mineral density and parameters of bone and mineral metabolism.

DESIGN:

Patients were treated in a randomized, double-blind controlled study with either placebo, 1 or 5 mg/day finasteride.

PATIENTS:

Twenty-three men with benign prostatic hyperplasia (BPH) were included in this study; eight received placebo, seven were allocated to treatment with 1 mg/day, and eight to 5 mg/day finasteride for 12 months.

MEASUREMENTS:

Vertebral bone mineral density was measured at the lumbar spine by dual energy X-ray bone densitometry. Serum calcium, phosphorus, parathyroid hormone, osteocalcin and vitamin D metabolites were measured regularly. Urinary calcium and creatinine excretion were monitored as well.

RESULTS:

Finasteride caused a significant decrease in serum dihydrotestosterone after 6 and 12 months, but no effect on serum testosterone. Vertebral bone mineral density remained unaltered. None of the other parameters monitored were affected except for a small unexplained increase in 1.25-dihydroxyvitamin D in the group receiving 5 mg finasteride/day.

CONCLUSIONS:

Testosterone is probably the active hormone in bone metabolism. However, oestradiol, the product of testosterone aromatization (which remains unaltered under finasteride) may yet be another possible responsible steroid in the maintenance of bone density. We can also not rule out that the small amount of dihydrotestosterone remaining under finasteride administration is sufficient for maintaining normal bone metabolism.

PMID:

1283117

[PubMed - indexed for MEDLINE]

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