三分之二的癌症是因"坏运气"造成的---Cancers: Two-thirds caused by bad luck

Science新年最新的一篇关于癌症的文章认为: 三分之二的癌症是因为"坏运气"（基因的随机变异，而这种变异是无法预防的）。环境和遗传因素占三分之一，但是好的生活方式还是要提倡的。

Vogelstein医生说：“人们常以为接触烟草等致癌物却不患癌症的长寿人士的秘诀是在于他们从父母那里继承了好的基因，但事实却是：他们当中的绝大多数人不过是运气较好而已。” 坏的生活方式是会加入到运气不好的因素里而得癌。

'Bad luck' of random mutations plays predominant role in cancer, study shows

 3D DNA model (stock image). It was well-known that cancer arises when tissue-specific
stem cells make random mistakes, or mutations, when one ...[show more] 

 

Scientists from the Johns Hopkins Kimmel Cancer Center have created a statistical model that measures the proportion of cancer incidence, across many tissue types, caused mainly by random mutations that occur when stem cells divide. By their measure, two-thirds of adult cancer incidence across tissues can be explained primarily by "bad luck," when these random mutations occur in genes that can drive cancer growth, while the remaining third are due to environmental factors and inherited genes.

 "All cancers are caused by a combination of bad luck, the environment and heredity, and we've created a model that may help quantify how much of these three factors contribute to cancer development," says Bert Vogelstein, M.D., the Clayton Professor of Oncology at the Johns Hopkins University School of Medicine, co-director of the Ludwig Center at Johns Hopkins and an investigator at the Howard Hughes Medical Institute.

"Cancer-free longevity in people exposed to cancer-causing agents, such as tobacco, is often attributed to their 'good genes,' but the truth is that most of them simply had good luck," adds Vogelstein, who cautions that poor lifestyles can add to the bad luck factor in the development of cancer.

Johns Hopkins的文章:  http://www.hopkinsmedicine.org/news/media/releases/bad_luck_of_random_mutations_plays_predominant_role_in_cancer_study_shows

论文原文:
http://www.sciencemag.org/content/347/6217/78

CBC新闻:

CBC News: Cancers: Two-thirds caused by bad luck

所有跟帖： 

• 谢谢分享，归根到底就是 基因和环境共同作用的结果。 -xuxinxuexi888- ♂ (0 bytes) () 01/03/2015 postreply 20:37:09

• 这不是说我们束手无策无事可做。健康生活充分休息，保持强大的免疫系统以消灭每一个“随机”产生的癌细胞就可以防癌。 -nyagela- ♀ (0 bytes) () 01/03/2015 postreply 20:54:26

• 说的好，我们做好能做的。 -xuxinxuexi888- ♂ (0 bytes) () 01/03/2015 postreply 20:57:22

• 你肯定免疫系统会消灭癌细胞吗？ -Big*Tree- ♂ (0 bytes) () 01/03/2015 postreply 21:36:30

• 本猫的理解，大概有一半的癌症，免疫系统能识别癌细胞并可以消灭少量癌细胞。免疫系统不能识别的癌细胞，免疫力再强也没用。 -nyagela- ♀ (6 bytes) () 01/03/2015 postreply 22:01:17

• 可以算得了猜想，如果是真的话，那么2/3癌症是机会产生的比较就可以下降。因为原文应该包括的一个假设是这些突变的癌细胞都有同等的机 -pichawxc- ♂ (0 bytes) () 01/04/2015 postreply 09:23:49

• 西医本来就没法把病理搞清楚，“看见的才是真实的”其实是错的。好多癌症是西医的治疗过程造成的。 -都是实话- ♂ (0 bytes) () 01/03/2015 postreply 21:54:30

• 啊？？？ -nyagela- ♀ (0 bytes) () 01/03/2015 postreply 22:49:16

• 呵呵，这样的文章更说明了主流治癌症（按文中说法至少是2/3的癌症）是两眼一抹黑。 -tournier- ♀ (0 bytes) () 01/04/2015 postreply 01:49:18

• "看见的才是真实的”是符合“实践是检验真理的唯一标准”的理论的。西医是 Evidence-Based-Medicine。 -happycow222- ♂ (582 bytes) () 01/04/2015 postreply 05:24:58

• 癌症村说明了环境污染是主要因素 -smeagolrocks- ♀ (0 bytes) () 01/04/2015 postreply 08:15:52

• 准确一点应该是：癌症村说明了环境污染是某些癌症产生的主要因素 -pichawxc- ♂ (0 bytes) () 01/04/2015 postreply 09:26:38

• 健康的生活与良好的环境，不能保证不得癌症；只是降低了得癌症的风险。文章只是量化了这个概念，登在科学杂志上，有些不够档次。 -小心一点- ♂ (0 bytes) () 01/04/2015 postreply 09:00:05

• 科学本身就包括可量化，这文章应该够档。否则，谁能猜出环境和生活方式导致癌症的比例大小呢？ -pichawxc- ♂ (0 bytes) () 01/04/2015 postreply 09:19:03

• 这个文章具体要看看是谁sponser的 -医者意也- ♂ (60 bytes) () 01/04/2015 postreply 09:14:42

• +100, 一针见血。 -东方白- ♂ (0 bytes) () 01/04/2015 postreply 14:07:40

• 如果是机遇问题，需要先从理论上解决，特别是突变理论的应用，有一个简单的例子： -RCHZ- ♂ (1157 bytes) () 01/04/2015 postreply 10:51:45

• 兄所论是有道理的。因此，癌因并未明——所有的科学家，医学家大师们都应当知道这个事实，因此，讨论抗癌与治癌，不要夸张。 -大江川- ♂ (0 bytes) () 01/04/2015 postreply 12:53:14

• 老是把搞不定的问题推到基因上去，这个态度很科学吗，倒是花了钱却办不了事的一个完美的借口 -ephd- ♂ (0 bytes) () 01/04/2015 postreply 11:05:23

• 有意思，一天前还怀疑呢 -苦人不哭- ♂ (105 bytes) () 01/04/2015 postreply 19:04:45