高血脂，氧化LDL，炎症反应和动脉硬化的发展及其防治- by YJ Xu (徐彦君 博士）

Anti-Atherosclerotic Molecules Targeting Oxidative Stress and Inflammation         from Current Pharmaceutical Design

Author(s): A. Adameova, Y. J. Xu, T. A. Duhamel, P. S. Tappia, L. Shan and N. S. Dhalla    

Pages 3094-3107 (14)

Abstract:

The accumulation of lipids within arteries remains to be the initial impulse for the pathogenesis of atherosclerosis; however, both inflammation and oxidative stress are considered to play a critical role in this process. Several lipid lowering drugs are used as the first line therapy in atherosclerosis; however, different agents have been found to exhibit beneficial effects which are independent of their lipid lowering activity. Both statins and fibrates have been reported to exert anti-inflammatory and anti-oxidative effects in addition to their anti-atherosclerotic actions. Furthermore, anti-hypertensive, anti-diabetic and anti-platelet drugs, which reduce oxidative stress and inflammation, have been shown to attenuate atherosclerosis. In addition, novel substances such as HDL-related agents, cyclopentenone prostaglandins, lipoprotein-associated phospholipase A2 inhibitors, 5-lipoxygenase pathway inhibitors, acyl CoA: cholesterol acyltransferase inhibitors, analogues of probucol and lysophosphatidic acid antagonists have been developed for the treatment of atherosclerosis as a consequence of their actions on oxidative stress and inflammation. The present article reviews the involvement of inflammation and oxidative stress in the pathogenesis of atherosclerosis and focuses on the mechanisms of some clinically used as well as potential anti-atherosclerotic substances with anti-inflammatory and anti-oxidative properties.

 

 

 

 

 

 

 

Keywords:

 

 

Atherosclerosis, inflammation, oxidative stress, statins, fibrates, novel anti-atherosclerotic drugs

 

 

 

 

 

 

 

Affiliation:

 

 

Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Center, 351 Tache Avenue, Winnipeg, Canada R2H 2A6.

所有跟帖： 

• 回复：高血脂，氧化LDL，炎症反应和动脉硬化的发展及其防治- by YJ Xu (徐彦君 博士） -tantema- ♂ (120 bytes) () 03/09/2014 postreply 06:20:32

• 简单易行：多吃五谷杂粮，新鲜瓜果蔬菜，喝些红酒，补些 Flaxseed油， Harp Seal 油， 沙棘 饮料，调料：葱姜蒜。 -tantema- ♂ (120 bytes) () 03/09/2014 postreply 06:24:05

• 还有：运动不可少。心情还要好。 -tantema- ♂ (0 bytes) () 03/09/2014 postreply 06:28:31

• 还有：择偶要当心，遗传是首要。好籽出好苗，好地收成好。父母同样病，子孙病歪歪。 -tantema- ♂ (72 bytes) () 03/09/2014 postreply 06:38:46

• 回复：还有：择偶要当心，遗传是首要。好籽出好苗，好地收成好。父母同样病，子孙发病高。不图一时乐，基因要选好。 -tantema- ♂ (0 bytes) () 03/09/2014 postreply 09:45:45