【一项小规模研究】X线检查不会增加乳癌风险

读到这样的一篇报道，贴出来让大家分析/发表意见。说实在的，要做X线诊断检查，也的确让人担忧，会犹豫不决。有时候是很难下决定的。

【X线检查不会增加乳癌风险】 诊断性X线检查在临床应用广泛，但人们普遍担心检查带来的辐射可增加患癌风险。这项病例对照研究给出了初步答案：即使对于高危的 BRCA1 (454例) 或 BRCA2 (273例) 突变携带者，X线检查也不会增加她们的乳癌风险。研究刊登在《Cancer Epidemiology Biomarkers Prevention》。cebp.aacrjournals.org/content/22/9/1547.abstract

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Abstract

Background: The effects of low-dose medical radiation on breast cancer risk are uncertain, and few studies have included genetically susceptible women, such as those who carry germline BRCA1 and BRCA2 mutations.

Methods: We studied 454 BRCA1 and 273 BRCA2 mutation carriers ages younger than 50 years from three breast cancer family registries in the United States, Canada, and Australia/New Zealand. We estimated breast cancer risk associated with diagnostic chest X-rays by comparing mutation carriers with breast cancer (cases) with those without breast cancer (controls). Exposure to chest X-rays was self-reported. Mammograms were not considered in the analysis.

Results: After adjusting for known risk factors for breast cancer, the ORs for a history of diagnostic chest X-rays, excluding those for tuberculosis or pneumonia, were 1.16 [95% confidence interval (CI), 0.64–2.11] for BRCA1 mutations carriers and 1.22 (95% CI, 0.62–2.42) for BRCA2 mutations carriers. The OR was statistically elevated for BRCA2 mutation carriers with three to five diagnostic chest X-rays (P = 0.01) but not for those with six or more chest X-rays. Few women reported chest fluoroscopy for tuberculosis or chest X-rays for pneumonia; the OR estimates were elevated, but not statistically significant, for BRCA1 mutation carriers.

Conclusions: Our findings do not support a positive association between diagnostic chest X-rays and breast cancer risk before the ages of 50 years for BRCA1 or BRCA2 mutation carriers.

Impact: Given the increasing use of diagnostic imaging involving higher ionizing radiation doses, further studies of genetically predisposed women are warranted. Cancer Epidemiol Biomarkers Prev; 22(9); 1547–56. ©2013 AACR.

 

• Received February 21, 2013.
• Revision received June 7, 2013.
• Accepted June 8, 2013.

• ©2013 American Association for Cancer Research.