转帖 － 膝关节退化治疗的未来式 :（PRP) 注射

膝關節退化治療的未來式:自體富血小板血漿(PRP)注射

分類：增生注射療法

2011/01/05 08:52

分享

FacebookPlurkYAHOO! 

這篇義大利波諾尼亞的研究, 透露出未來的膝關節退化治療模式, 除了補充葡萄糖胺/玻尿酸注射與微創/置換手術之外, 將會有一股新興的潮流出現.

依照此研究結果, 膝關節退化的患者, 只要將自己的靜脈血抽出約150cc, 經離心後自其中析離出富含血小板之自體血漿(platelet-rich plasma), 然後再將這個PRP注射回自己退化的膝蓋中, 療效將持續至少一年.

 

 

 

與目前關節注玻尿酸比較起來, PRP注射將帶來許多治療上的優勢:

1. 注射劑來源更天然 (由雞冠萃取轉為自體血萃取,較有保護動物之意識,素食者也可注射)

2. 注射頻率更少 (玻尿酸一年至少要注射3~10劑)

3. 治療效果應更完全 (從玻尿酸的輔助修補到PRP的直接參與修補)

 

然而, 目前關於這方面的研究尚未全面而完整, 仍有許多實際的臨床問題需要回答:

1. 退化性關節炎注射PRP的時機? 劑量? 次數? 

2. PRP注射與玻尿酸注射, 何者療效較佳?

3. PRP注射, 可否成功治療玻尿酸注射無效, 卻又無法/不願接受手術的患者?

4. 同樣是退化性關節炎, PRP可否同時成功治療髖關節/踝關節/肩關節等部位?

......

 

種種的問題, 還期待醫學先進們為我們逐步找到解答, 但可以確定的是, 在可預見的數年內, 國人就可以享受到PRP新科技帶來的好處.

 

[相關閱讀]

血小板生長因子於筋骨再生/修補的醫學實證

以富含血小板之血漿(PRP)注射慢性筋骨疼痛網站: ApexPRP

值得期待的增生劑:自體血小板濃縮液 APC, autologous platelet concentrate

PRP可促進試管中人類肌腱細胞的創傷後再生癒合作用 (AJSM 2008)

以富涵生長因子之自體血漿注射外踝部, 可成功治療第三度踝關節扭傷

血小板生長因子可促進關節膜細胞分泌玻尿酸

 

[原文摘要]

Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):472-9.

Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions.

Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M.

Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Bologna, Italy. [e-mail]

Abstract

Platelet-rich plasma (PRP) is a natural concentrate of autologous blood growth factors experimented in different fields of medicine in order to test its potential to enhance tissue regeneration. The aim of our study is to explore this novel approach to treat degenerative lesions of articular cartilage of the knee. One hundred consecutive patients, affected by chronic degenerative condition of the knee, were treated with PRP intra-articular injections (115 knees treated). The procedure consisted of 150-ml of venous blood collected and twice centrifugated: 3 PRP units of 5 ml each were used for the injections. Patients were clinically prospectively evaluated before and at the end of the treatment, and at 6 and 12 months follow-up. IKDC, objective and subjective, and EQ VAS were used for clinical evaluation. Statistical analysis was performed to evaluate the significance of sex, age, grade of OA and BMI. A statistically significant improvement of all clinical scores was obtained from the basal evaluation to the end of the therapy and at 6-12 months follow-up (P < 0.0005). The results remained stable from the end of the therapy to 6 months follow up, whereas they became significantly worse at 12 months follow up (P = 0.02), even if still significantly higher respect to the basal level (P < 0.0005). The preliminary results indicate that the treatment with PRP injections is safe and has the potential to reduce pain and improve knee function and quality of live in younger patients with low degree of articular degeneration.

 

PMID:19838676

所有跟帖： 

• 加上点自体间充质干细胞， 效果 would be better. 呵呵。 -堪诚- ♂ (0 bytes) () 07/12/2011 postreply 15:30:37

• 有一门很大的分支:regenerative medicine(再生医学?)就是专门研究这些课题的.. -weston- ♀ (0 bytes) () 07/12/2011 postreply 17:29:17

• 不光是对膝关节有效,我昨晚贴的视频有介绍 -weston- ♀ (0 bytes) () 07/12/2011 postreply 17:13:36

• 我30多年的风湿关节炎，用自创的一种纯中医方法彻底根治，9年未复发。比之(prp)注射 -孤舟渔翁- ♂ (50 bytes) () 07/12/2011 postreply 20:50:40

• 你的方法呢？ 讲出来听听。 -心荷- ♀ (0 bytes) () 07/13/2011 postreply 12:55:11

• 7，8年前，方法和原理都在医学杂志上发表过，没用的。生气！现在只讲原理，不讲方法。 -孤舟渔翁- ♂ (53 bytes) () 07/14/2011 postreply 19:52:03