回复：回复：You should never use HbA1c to diagnose diabetes

Pepper, I'm so impressed with your medical knowledge. It's always a pleasure to read your posts and discuss with you on interesting issues. Actually, there are physicians who make a diangosis of diabetes based on HbA1c alone - the diagnosis should be confirmed by the approved diagnostic tests.

In order for a test to be used to diagnose a certain disease, it has to be sensitive and specific. The problem with HbA1c testing is that it is not very well standardized, the HbA1c value can be affected by multiple factors, eg, pregnancy, infection, autoimmune disorder, hemoglobinopathies, etc. Sure a high HbA1c can reflect high blood glucose level, but a normal HbA1c or a low HbA1c cannot exclude diabetes -- that's why ADA does not recommend it as a diagnostic criteria.

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• 回复：Thanks -laoyueyue- ♀ (0 bytes) () 01/21/2009 postreply 03:32:40