多大联系? 比较小, 但不是绝对零;
很多癌症基因? 没这回事.
肝癌(HCC) is very common in China, why? Because China is (at least was) world capital of HBV, not because chinese people carry bad genes. Familial HCCs do occur, but are exclusively results from familial viral cross-infections, not from germline gene mutation. There is no known HCC-causing gene. You could have slightly higher risk of HCC if you carry polymorphism of certain gene, such as one GST subenzyme that is responsible for aflatoxin detoxification. Even if this is true with you, such gene (or the null of it) still does not qualify as "肝癌基因" - only a loose association. This resembles p450 in the case of smoker lung cancer.
There is no high-penetrance gene for bladder cancer either. Germline mutation in low-penetrance genes such as TP53 or RB1 can occur, but only at extremely low frequency. Further, if you indeed harbor TP53, RB1, or Hras germline mutation, you probably have already displayed some very apparent genetic and oncologic abnormalities by now due to early onset LOH.
Bottomline, your risk of getting cancer maybe higher than people who have no family cancer history because your once-shared environment and family life habits, but it is unlikely the higher risk is the result of your inheritance. Your chance of getting cancer from faulty gene (与生俱来的) is quite tiny, compare to your risk of getting cancer from other factors (可预防的,自找的), such as
- HBV infection 乙肝
- alcoholic liver damage 酒精硬肝
- aflatoxin 黄曲霉
- anything that causes mutation to your own somatic gene, such as radon, x-ray, solvent, chemical 突变
- high salt diet 高浓度
Just my personal opinion. If you lose sleep worrying, should call a professional genetic counselor to straighten out.
很多癌症基因? 没这回事.
肝癌(HCC) is very common in China, why? Because China is (at least was) world capital of HBV, not because chinese people carry bad genes. Familial HCCs do occur, but are exclusively results from familial viral cross-infections, not from germline gene mutation. There is no known HCC-causing gene. You could have slightly higher risk of HCC if you carry polymorphism of certain gene, such as one GST subenzyme that is responsible for aflatoxin detoxification. Even if this is true with you, such gene (or the null of it) still does not qualify as "肝癌基因" - only a loose association. This resembles p450 in the case of smoker lung cancer.
There is no high-penetrance gene for bladder cancer either. Germline mutation in low-penetrance genes such as TP53 or RB1 can occur, but only at extremely low frequency. Further, if you indeed harbor TP53, RB1, or Hras germline mutation, you probably have already displayed some very apparent genetic and oncologic abnormalities by now due to early onset LOH.
Bottomline, your risk of getting cancer maybe higher than people who have no family cancer history because your once-shared environment and family life habits, but it is unlikely the higher risk is the result of your inheritance. Your chance of getting cancer from faulty gene (与生俱来的) is quite tiny, compare to your risk of getting cancer from other factors (可预防的,自找的), such as
- HBV infection 乙肝
- alcoholic liver damage 酒精硬肝
- aflatoxin 黄曲霉
- anything that causes mutation to your own somatic gene, such as radon, x-ray, solvent, chemical 突变
- high salt diet 高浓度
Just my personal opinion. If you lose sleep worrying, should call a professional genetic counselor to straighten out.
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