Once H. pylori is detected in patients with a peptic ulcer, the normal procedure is to eradicate it and allow the ulcer to heal.
The standard first-line therapy is a one week triple therapy(三联药法) consisting of the antibiotics amoxicillin 阿莫西林and clarithromycin克拉霉素, and a proton pump inhibitor such as omeprazole 奥美拉唑 .
Common antibiotics combinations are:
Clarithromycin (Biaxin) and amoxicillin (Amoxil, Trimox)
Metronidazole (Flagyl) and amoxicillin (Amoxil, Trimox)
Metronidazole (Flagyl) and tetracycline (Sumycin)
Variations of the triple therapy have been developed over the years, such as using a different proton pump inhibitor, as with pantoprazole or rabeprazole, or replacing amoxicillin with metronidazole for people who are allergic to penicillin.
Such a therapy has revolutionized the treatment of peptic ulcers and has made a cure to the disease possible; previously the only option was symptom control using antacids, H2-antagonists or proton pump inhibitors alone.
有时用三联药法治疗后会出现抗药性.
An increasing number of infected individuals are found to harbour antibiotic-resistant bacteria. This results in initial treatment failure and requires additional rounds of antibiotic therapy or alternative strategies such as a quadruple therapy(四联法), which adds a bismuth colloid. For the treatment of clarithromycin-resistant strains of H. pylori the use of levofloxacin 左氧氟沙星<喹诺酮类抗菌药>as part of the therapy has been suggested.
http://www.mayoclinic.com/health/h-pylori/DS00958/DSECTION=treatments-and-drugs
The standard first-line therapy is a one week triple therapy(三联药法) consisting of the antibiotics amoxicillin 阿莫西林and clarithromycin克拉霉素, and a proton pump inhibitor such as omeprazole 奥美拉唑 .
Common antibiotics combinations are:
Clarithromycin (Biaxin) and amoxicillin (Amoxil, Trimox)
Metronidazole (Flagyl) and amoxicillin (Amoxil, Trimox)
Metronidazole (Flagyl) and tetracycline (Sumycin)
Variations of the triple therapy have been developed over the years, such as using a different proton pump inhibitor, as with pantoprazole or rabeprazole, or replacing amoxicillin with metronidazole for people who are allergic to penicillin.
Such a therapy has revolutionized the treatment of peptic ulcers and has made a cure to the disease possible; previously the only option was symptom control using antacids, H2-antagonists or proton pump inhibitors alone.
有时用三联药法治疗后会出现抗药性.
An increasing number of infected individuals are found to harbour antibiotic-resistant bacteria. This results in initial treatment failure and requires additional rounds of antibiotic therapy or alternative strategies such as a quadruple therapy(四联法), which adds a bismuth colloid. For the treatment of clarithromycin-resistant strains of H. pylori the use of levofloxacin 左氧氟沙星<喹诺酮类抗菌药>as part of the therapy has been suggested.
http://www.mayoclinic.com/health/h-pylori/DS00958/DSECTION=treatments-and-drugs
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