Salvia miltiorrhizae, a traditional Chinese herb, has been studied for its potential benefits in treating chronic kidney disease (CKD). The estimated glomerular filtration rate (eGFR) is a widely used test to measure kidney function and stage kidney disease.
eGFR and Kidney Function
The eGFR is calculated from blood creatinine levels, age, body size, and gender. A low eGFR indicates potential kidney issues. Regular tests and managing health can protect kidney function.
Salvia miltiorrhizae and eGFR
Studies have shown that Salvia miltiorrhizae or its extracts, such as Salvianolic acid B and Tanshinone IIA, may improve kidney function in CKD patients by:
- Increasing glomerular filtration rate (GFR) and creatinine clearance (Ccr)
- Reducing serum creatinine (SCr) and proteinuria
- Delaying the progression of CKD
A systematic review and meta-analysis found that Salvia miltiorrhizae as a complementary therapy to conventional medicine presents potential impacts to improve kidney functions and delay the progression of CKD without obvious adverse effects.
Kidney Disease Stages and eGFR
The eGFR measures kidney function and stages of kidney disease. A low eGFR indicates potential kidney issues. The stages of CKD are:
- Stage 1: Kidney damage with normal kidney function (eGFR ≥ 90)
- Stage 2: Mild to moderate loss of kidney function (eGFR 60-89)
- Stage 3: Moderate to severe loss of kidney function (eGFR 30-59)
- Stage 4: Severe loss of kidney function (eGFR 15-29)
- Stage 5: Kidney failure (eGFR < 15)
Conclusion
Salvia miltiorrhizae has shown promise in improving kidney function and delaying the progression of CKD. However, more research is needed to fully understand its effects on eGFR and kidney disease stages. Patients with CKD should consult their healthcare team for personalized guidance and treatment plans.
- What are the specific mechanisms by which Salvia miltiorrhizae extracts improve glomerular filtration rate?
- How does Salvia miltiorrhizae compare to established pharmaceutical treatments for CKD in terms of efficacy and side effects?
- Can Salvia miltiorrhizae supplementation slow or halt kidney disease progression in patients with advanced CKD (Stage 4 or 5)?
