铁 (1)，它竟是致命的罪魁祸首，每年导致 1100 万慢性病人的死亡。

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金猪宝（2024年3月13日）

经过长时间的研究，我终于找到了导致慢性病人死亡的真正罪魁祸首。铁是造成世界上每年约 1100 万人死亡的主要原因（并非全部原因）。这个发现让我自己都震惊了。它与全球每天约 30, 0000 人死亡有关。

《部分摘要》：铁剂输注自 19 世纪初以来一直用于治疗贫血，并于 50 世纪获得认可。以后的研究证实，异常的铁会损害患者的所有细胞、所有器官和所有部位，并加速各种癌症的生长。在大量变量的影响下，异常的铁以不可预测的方式通过多种机制导致细胞损伤......我将展示为什么铁引起的副作用在临床上经常被忽视，为什么铁引起的副作用比想像更普遍、更致命。为什么铁引起的副作用被忽视或未被识别或误认为是感染/药物的副作用，以及它们如何对患者造成广泛的、无症状的、非特异性的（通常像疾病和药物的作用）、进行性的、常常无法识别、未被充分认识的细胞损伤。我证明铁毒性是破坏人体健康的主要手段，影响着全球超过 10 亿贫血人群……。

铁是必不可少的。人没有铁就一分钟无法生存。铁就像一个核武器；当被国家当局很好地控制时，没问题。然而，当它被坏人控制时，放在京城省会时，那会是什么结果呢？

当铁过量或调节不当时，它会损坏细胞中的DNA、蛋白质、脂肪和所有生物材料。它干扰所有生物过程、免疫系统等，并且可以加速各种癌症的生长！中风、心脏病、高血压、各种结石、组织钙化等等都可追到这个杀手！在看到这些引用的研究之前，没有人会相信这一点。

医院使用的大多数医疗方法都是基于 1950 或1980 年以前的知识。这些参考文献引用的研究大部分是2010年至2023年的。每天的新发现都可能震惊世界，但会被利益集团封锁。参考文献只是一小部分，因为许多期刊没有在我检索的数据库中建立索引。想想都觉得可怕。大多数医生都会犯致命的错误：他们会带着配偶和孩子去医院治疗慢性病，而不知道医院使用方法存在巨大的知识滞后。

简而言之，铁在人体内的代谢和运输必须严格控制和监管，以避免它的致命祸害。当人出现炎症时，某些炎症细胞因子会导致铁的代谢和运输失调，导致铁在一些重要器官如肝脏、肺等积累。过量的铁会产生OH-自由基。 OH-自由基的出现会导致更严重要器官炎症和全身炎症。加重的炎症会导致更严重的铁的失调，开始恶性循环（更多的铁，更多OH-自由基，更严重的炎症，器官内更多的铁，更多自由基，更严重的炎症，更大破坏力，永远持续下去），直到杀死患者。即使患者血液中缺乏铁，或患有所谓的缺铁性贫血（甚至疾病名称也有误导性），这种恶性循环情况也可能发生（而且常常发生）。

我的2万多字文章将会发表。然而，这篇文章需要很长时间才能发表。当我想到每天的死亡人数约为30000人时（5400000 半年），我不能沉默。当一个人知道影响这么多人命的秘密不说，那是太缺德了。

我不能在这里讨论所有的发现，但会在这个系列中讨论许多相关的问题。虽然慢性病的潜在解决方案很复杂并且取决于个体的情况，但目前的治疗方法、用铁剂量等等都是错误的。我的研究结论为所有慢性病治疗指出了新的方向。我希望这post能给有人们一个提示，使他们能够避免医疗系统的致命治疗方法。为了显示证据的强度，我提供了我审阅过的大部分参考文献。

奇怪的是，每个项发表的研究都只谈自己的结论，它不提它的结论意味着千百万人的命！研究者更不会把千万的研究结论（包括其他的已知的死因）一起考虑，他们没有胆量说铁是所有慢性病致命的罪魁祸首（中风、心脏病、高血压、结石、组织钙化等等，看起来不明显）。我的结论意味着慢性病不治论很快就要彻底倒了。我想以后研究还要探讨其他金属在什么情况下对慢性病人有相似的效应。

一个很有用的要发明的仪器是测人体铁分布仪，靠检查测磁场或铁元素的共振。铁分布图能确定铁在不同器官的浓度和危害程度。难处是要达到很高的灵敏度。

参考文献（在最后）

English version

Iron (1), it is the most deadly weapon affecting 11 millions of chronic disease deaths each year.

From my long study, I finally got the real culprit of deaths. Iron is the killing weapon employed by all chronic diseases and is mainly (not entirely) responsible for about 11 million deaths in the world.

The finding shocks myself. It is mainly responsible for about 30, 0000 deaths each day in the world.

Partial findings: Iron infusion has been used for treatment of anemia since the early 19 century and gained acceptance in the 50th. Subsequent studies have firmly established that aberrant iron can damage all cells, all organs, and all parts in the patient, and accelerate cancer growth for all kinds of cancer. Aberrant iron causes cellular damage by multiple mechanisms in an unpredictable manner under influences of a large number of variables.... I show why iron-induced adverse effects are routinely dismissed in clinic, why they are magnitudes more prevalent and more deadly than what are believed, why they were ignored or unrecognized or mistaken as those of infections/drugs, and how they cause widespread, asymptomatic, nonspecific (often mimic those of diseases and drugs), progressive, often unrecognizable, and under-appreciated cellular damages to the patient. I prove that iron toxicity is the primary arm for ruining host health, affecting more than a billion anemic people globally….

Iron is essential. A person cannot survive for one minute without iron. Iron is like a great nuclear weapon for nation when iron is controlled well by the national authority. However, when it is controlled by a wrong hand, and is placed in the capital city, and province capitals, what would be the outcome? Destruction of the nation!

Iron is just like nuclear weapon: when iron is in excess or under-regulated (uncontrolled), it can damage DNA, protein, fat and all biological materials in cells. It can interfere with all biological processes, the immune system, etc. and it can speed up cancer growth for all kinds of cancer. Stroke, heart disease, high blood pressure, all kinds of stones can be traced this evil killer! No one can believe it before seeing those cited studies.

Most practices used by hospitals are based on knowledge of 1950 for before. Those references cited studies are most from 2010 to 2023. Chances are that new discoveries could shock the world but not suppressed by interest holders. The references are only a small set because many journals are not indexed in the databases I searched. It is scared to think about it.

Most doctors would make deadly mistakes: they will bring their spouses and children to hospitals for treating chronic diseases without knowing the huge knowledge lag.

To state the story in short: Iron must be tightly controlled and regulated to avoid iron’s deadly effects. When a person has inflammation, certain inflammatory cytokines will lead to dis-regulation of iron metabolism and transportation, and will cause iron to be accumulated in some vital organs such as liver, lungs, etc. The excess iron is responsible for generating radicals, which can cause more inflammation in both the vital organs and the whole body. It cause more iron disregulation, starting the vicious circle (more iron, more inflammation, or destructive force, keeping on forever) until the uncontrolled iron kills the patient. This can happen even when the patient lacks iron in blood or suffer so-called iron-deficiency anemia (even the disease name used in medicine is misleading).

The 20,000-words article will be published. However, it would take a long time to have the article published. When I think the death count is about 30,000 a day, I cannot do nothing in the scam medical publication system.

I cannot put massive discoveries here, but I will discuss many related problems in a series. While potential solutions to chronic diseases are complicated and depend on individual conditions, it is wrong to use iron in the current methods, dosages, etc. The findings also point to a new direction for treating chronic diseases. I hope this post will give thinking people a hint so that they can avoid the deadly consequences in the health care system. To show the strength of evidence, I provide most references I have reviewed.

What is strange is that each published study only talks about its own conclusions. It does not mention that its conclusions mean millions of lives! Researchers will not consider the conclusions of tens of millions of studies (including those about other known causes of death) together. They have no guts to say that iron is primarily responsible for deaths in all chronic diseases (the roles of iron in stroke, heart disease, high blood pressure, stones, tissue calcification, etc. are not obvious). My conclusion means that incurable notion of chronic diseases will soon completely repudiated. I think future research will also explore under what circumstances other metals have similar effects on chronic disease patients.

A very useful instrument to be invented is a human iron distribution machine, which detects magnetic fields or resonances of iron elements. An iron mapping can determine iron local concentrations and degrees of harm of iron in different organs. One obvious difficulty is how to achieve very high sensitivity.

[end]

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102. Kim JL, Lee D-H, Na YJ, et al. Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells. Tumour Biol. 2016;37:9709–9719
103. de Juan D, Reta A, Castiella A, et al. HFE gene mutations analysis in Basque hereditary haemochromatosis patients and controls. Eur J Hum Genet. 2001;9:961–964.
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109. Huang X: Iron overload and its association with cancer risk in humans: Evidence for iron as a carcinogenic metal. Mutat Res. 2003;533:153–171.
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119. WEINBERG, ED Iron withholding: a defense against infection and neoplasia. Physiol. Rev. 1984;64,65.
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123. Roemhild K, von Maltzahn F, Weiskirchen R, et al. Iron metabolism: Pathophysiology and Pharmacology. Trends Pharmacol Sci. 2021 August 01;42(8):640–656. doi:10.1016/j.tips.2021.05.001. (In patients with iron overload, such as HH, the risk of HCC (a liver cancer) is increased by up to 200-fold.)
124. Dev S, Babitt JL. Overview of Iron Metabolism in Health and Disease. Hemodial Int. 2017 June;21(Suppl 1):S6–S20. doi:10.1111/hdi.12542.
125. Feldman HI, Santanna J, Guo W, et al. Iron administration and clinical outcomes in hemodialysis patients. J Am Soc Nephrol. 2002; 13: 734-744 (There is increasing data to suggest that infective and adverse-event risks may be related to the intensity and frequency of IV iron dosing)
126. Shah AA. Donovan K, Seeley C, et al. Risk of Infection Associated With Administration of Intravenous Iron: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(11):e2133935. doi:10.1001/jamanetworkopen.2021.33935) (all kinds of infections)
127. Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials. BMJ. 2013; 347: f4822 (A recent meta-analysis of randomized controlled trials evaluating IV iron use (often administered as frequent boluses) in patients with varying infective risk profiles found IV iron to be associated with 30% greater risk of infection compared to oral or no iron therapy.
128. Gonçalves JL, Silva MCA, Roma EH, et al. Iron intake is positively associated with viral load in antiretroviral naïve Brazilian men living with HIV. Mem Inst Oswaldo Cruz. 2019; 114: e190350. Doi: 10.1590/0074-02760190350
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130. Salama KM, Ibrahim OM, Ahmed M. Liver Enzymes in Children with beta-Thalassemia Major: Correlation with Iron Overload and Viral Hepatitis. Open Access Maced J Med Sci. 2015 Jun 15; 3(2): 287–292. doi: 10.3889/oamjms.2015.059 (Iron overload is a main leading cause of elevated liver enzymes, and presence of hepatitis-C virus infection is significantly related to the increased iron overload.)
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139. David V, Francis C, Babitt JL. Ironing out the cross talk between FGF23 and inflammation. Am J Physiol Renal Physiol. 2017; 312(1):F1–F8. (The protective effects of iron deficiency for malaria, diarrheal illnesses, and tuberculosis in the developing world is supported by the increased rate of these infections and their associated morbidity and mortality.
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141. La Carpia, F, Wojczyk BS, Annavajhala MK. Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron. npj Biofilms Microbiomes 2019;5, 26. https://doi.org/10.1038/s41522-019-0097-2. (These iron interventions have consistent and reproducible effects on the murine gut microbiota; specifically, relative abundance of the Parabacteroides and Lactobacillus genera negatively correlate with increased iron stores, whereas members of the Clostridia class positively correlate with iron stores regardless of the route of iron administration.)
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146. Brookhart MA, Freburger JK, Ellis AR, Wang L. Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients. J Am Soc Nephrol. 2013; 24:1151-1158. (the authors studied iron dosing patterns in a retrospective cohort of 117,050 prevalent hemodialysis patients and found that administration of large boluses of IV iron for repleting iron deficiency was associated with increased infection-related hospitalization or death (adjusted hazard ratio, 1.08; 95% confidence interval, 1.05-1.11) compared with smaller doses of IV iron maintenance therapy. The risk of infection-related hospitalization was increased further in patients who had experienced infection within the past month.
147. Rozen-Zvi B, Gafter-Gvili A, Paul M, et al. Intravenous versus oral iron supplementation for the treatment of anemia in CKD: systematic review and meta-analysis. Am J Kidney Dis. 2008; 52: 897-906 (Unfortunately, similar trials in patients with CKD seldom report bacterial infections as an end point. Iron toxicity can diminish patient’s ability to defend against microbial infections. Based on mice model study, iron overload inhibits the release of NETs and ROS production in neutrophils isolated from mice fed a high-iron diet.
148. David V, Martin A, Isakova T, et al. Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. Kidney Int. 2016; 89(1):135–146. [bone]
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159. Frost JN, Wideman SK, Preston AE. Plasma iron controls neutrophil production and function. Sci Adv. 2022 Oct; 8(40): eabq5384. doi: 10.1126/sciadv.abq5384 (Mice given mHep to remove iron from liver had fewer neutrophils and eosinophils, but unchanged Ly6C+ and Ly6C−monocyte frequency, in the spleen and blood.)
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166. Wu J, Zha P. Clinical trials cannot provide sufficient accuracy for studying weak factors necessary for curing chronic diseases. Glob J Cancer Ther. 2022;8(1):021-033. DOI: 10.17352/2581-5407.000044;
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