Melisaa Moore, chief scientific officer at Moderna:
“We aim for a turnaround time of 45 days. … Thus, when the sequence of the SARS-CoV-2 virus was posted to a public web server on January 10, 2020, we got immediately to work. Within two days, we had agreed with our collaborators at NIH on exactly which form of the spike protein to put in our vaccine. Because we had done so so many times before, it then took our mRNA design team just one hour to design the mRNA that we immediately –
That we immediately put on to our manufacturing equipment. We were then able to make that RNA, get it quality-controlled, fill-finished and shipped off to NIH for the clinical trial in 45 days.”
Google translate:
Moderna 首席科学官 Melisaa Moore:
“我们的目标是 45 天的周转时间。 ……因此,当 SARS-CoV-2 病毒的序列于 2020 年 1 月 10 日发布到公共网络服务器时,我们立即开始工作。 两天之内,我们与 NIH 的合作者就在我们的疫苗中加入哪种形式的刺突蛋白达成了一致。 因为我们之前已经做过很多次了,所以我们的 mRNA 设计团队只用了一个小时就设计出了我们立即——
我们立即将其安装到我们的制造设备上。 然后我们就能够制造出这种 RNA,对其进行质量控制、填充完成并在 45 天内运往 NIH 进行临床试验。”
见: 12分45秒起