【nature自然】断食与COVID免疫能力相关。生酮补酮可以加强对抗病毒

https://www.nature.com/articles/s42255-022-00646-1

BHB 的产生减少与重症 COVID-19 患者的 CD4 + T 细胞功能受损相关，通过生酮饮食或口服酮酯补充 BHB 可提高 CD4 + T 细胞的存活率及其产生干扰素的能力。 γ (IFNγ)，从而增强抗病毒免疫反应6 (图1 )。

总体而言，本研究已将酮体 BHB 确定为线粒体 OXPHOS 燃料的替代碳源，从而在感染诱导的厌食症条件下对T H 1 细胞进行代谢重编程并提高抗病毒免疫。考虑到 BHB 3的多种细胞信号活性，BHB有可能通过转录调控或表观遗传修饰等其他方式改变 CD4 + T 细胞功能

酮体β-羟基丁酸（BHB）

In a recent study published in Nature, Karagiannis et al. show that attenuated production of BHB is correlated with impaired CD4+ T cell function in patients with severe COVID-19, and BHB supplementation through a ketogenic diet or oral administration of ketone esters enhances survival of CD4+ T cells and their capacity to produce interferon-γ (IFNγ), thereby boosting the antiviral immune response6 (Fig. 1).

Overall, this study has identified the ketone body BHB as an alternative carbon source to fuel mitochondrial OXPHOS, thereby metabolically reprogramming TH1 cells and improving antiviral immunity in conditions of infection-induced anorexia

数据看这里。

https://www.nature.com/articles/s41586-022-05128-8

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