具体数据见内

The data published in UK vaccine surveillance reports (August 16, 2021-March 27, 2022) was used for the analysis. The ≥18 years of age two doses vaccinated population showed vaccine effectiveness of 17.5% (95% CI 16.5%-18.4%) for the four weeks period ending September 12, 2022. Ever since, the vaccinated with two doses and the third dose (since December 20, 2021) have negative vaccine effectiveness with the vaccinated population having a greater proportion of cases than the unvaccinated. The UKHSA did not report third dose outcomes until December 20, 2021 in their weekly reports. In our study, we analyzed the 336,046 cases among the third booster pillar 2 population (November 27, 2021-January 12, 2022) and using the third dose weekly vaccinated population between December 26, 2021 to January 9, 2022, the best vaccine effectiveness for the third dose was 13.8%, 18.4%, and 22.2%, respectively. The proportion test showed that the all-vaccinated population have higher proportion of cases than the unvaccinated since August 23, 2021 (X2 = 11.686, df = 1, p = 0.0003149) and since the third dose reporting period of December 20, 2021 (X2 = 79651, df = 1, p<0.001). Of the vaccinated populations, the vaccinated with two doses have significantly higher proportion of cases since August 30, 2021. Since January 31, 2022; the third dose vaccinated population have significantly higher proportion of cases than two doses (X2 = 368.53, df = 1, p<0.001) and unvaccinated (X2 = 55147, df = 1, p<0.001). The proportions test also showed that over 18 years old two doses vaccinated population have significantly higher proportion of hospitalizations than unvaccinated (X2 = 332.3, df = 1, p<0.001) since December 6, 2021 and since January 17, 2022 all vaccinated population have significantly higher proportion of hospitalizations than unvaccinated (X2 = 14.103, df = 1, p<0.001). Since January 24, 2022, the third dose population also have a higher proportion of hospitalizations than unvaccinated (X2 = 33.446, df = 1, p<0.001). Since February 14, 2022 the third dose population have higher proportion of hospitalizations than two doses (X2 = 25.946, df = 1, p<0.001) and unvaccinated (X2 = 121.11, df = 1, p<0.001). The proportion test on deaths also showed a significantly higher proportion of deaths among vaccinated over 18 years old with two doses than unvaccinated since September 13, 2021 (X2 = 7.6872, df = 1, p = 0.0028), all vaccinated population higher proportion of deaths than unvaccinated since January 10, 2022 (X2 = 41.017, df = 1, p<0.001) and third dose higher (X2 = 53.465, df = 1, p<0.001)