FDA 把Clonazepam 列为pregnancy category D,是指除非一定要控制病情或无其它替代法,是不建议用的,因为有风险.但到目前为止孕妇服用Clonazepam后致使胎儿不正常的报道仍然有限.FDA能给的是动物实验数据和抗焦虑药苯二氮卓类的整类中其它药物的使用警告:
1.看FDA这一链接的第五、六页:
http://www.accessdata.fda.gov/clonazepam
第六页上:
Because of experience with other members of the benzodiazepine class, Klonopin is assumed to be capable of causing an increased risk of congenital abnormalities when administered to a pregnant woman during the first trimester. Because use of these drugs is rarely a matter of urgency in the treatment of panic disorder, their use during the first trimester should almost always be avoided. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Patients should also be advised that if they become pregnant during therapy or intend to become pregnant, they should communicate with their physician about the desirability of discontinuing the drug.
2.Clonazepam Pregnancy and Breastfeeding Warnings:
http://www.drugs.com/pregnancy/clonazepam