Sounds like the astrocytoma you are talking about is WHO grade II, low grade glioma. I hope the pathology is well-differentiated fibrillary astrocytoma so the patient is younger with a more favorable prognosis.
However, the nature history of this grade II tumor is that 50% of surgically treated lesions evolve into anaplastic astrocytoma or GBM. In fact degeneration nto a higher-grade tumor is the most common cause of death in patients with low-grade astrocytoma.
Therefore, surgical resection with a large margin is the best option especially if lesion is not in the motor or speak regions of the brain, like in the case presented. In US, typical treatment is resection of the tumor with Gliadel implant in the resection cavity. Even after resection, some also do radiation because the real margin of the tumor is really no known by imaging. Interventional therapy is not useful.
Hope that helps.
However, the nature history of this grade II tumor is that 50% of surgically treated lesions evolve into anaplastic astrocytoma or GBM. In fact degeneration nto a higher-grade tumor is the most common cause of death in patients with low-grade astrocytoma.
Therefore, surgical resection with a large margin is the best option especially if lesion is not in the motor or speak regions of the brain, like in the case presented. In US, typical treatment is resection of the tumor with Gliadel implant in the resection cavity. Even after resection, some also do radiation because the real margin of the tumor is really no known by imaging. Interventional therapy is not useful.
Hope that helps.
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