介绍一篇关于抗氧化剂与肺腺癌的文章

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N-Acetyl-L-Cysteine (NAC), 中文名:N-乙酰-L-半胱氨酸

前些年挺流行的一种抗氧化剂,被人们用来抗炎症、防衰老………。还有些人用来清肺,治疗肺气肿。

 

但是,有利则有弊,麻烦来了。下面的研究发现,这东东在小鼠诱发肺腺癌。

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795405/

The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice

Oxidative stress is a major contributor to chronic lung diseases. Antioxidants such as N-acetylcysteine (NAC) are broadly viewed as protective molecules that prevent the mutagenic effects of reactive oxygen species. Antioxidants may, however, increase the risk of some forms of cancer and accelerate lung cancer progression in murine models. Here, we investigated chronic NAC treatment in aging mice displaying lung oxidative stress and cell senescence due to inactivation of the transcription factor JunD, which is downregulated in diseased human lungs. NAC treatment decreased lung oxidative damage and cell senescence and protected from lung emphysema but concomitantly induced the development of lung adenocarcinoma in 50% of JunD-deficient mice and 10% of aged control mice. This finding constitutes the first evidence to our knowledge of a carcinogenic effect of antioxidant therapy in the lungs of aged mice with chronic lung oxidative stress and warrants the utmost caution when considering the therapeutic use of antioxidants.

 

有兴趣的,自己去看细节。

 

多余的话

当下各种营养品、保健品、补品、精品、……品泛滥。

尤其是“抗氧化”、抗衰老之类的东东。切记,癌细胞可是永葆青春、活力四射的……

 

请不要赶时尚,花大钱,争当第一批小老鼠。等个三五年,前浪消失在沙滩上……明白咋回事了,再下嘴不迟。

 

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谢谢夫子兄分享与提醒。 -kingfish2010- 给 kingfish2010 发送悄悄话 kingfish2010 的博客首页 (0 bytes) () 08/26/2021 postreply 12:44:34

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