你这个担忧很有道理啊! 即使是pd1抑制剂药物,这种自身免疫反应副作用也不罕见。

这篇报道里的例子就是联用PD-1抑制剂和ctla 4抗体,免疫系统攻击癌细胞很有效,但也攻击胰脏,引起急性I型糖尿病。癌细胞控制住了,胰脏牺牲了。

... the autoimmune reactions were seen not only as an acceptable cost of these drugs but as evidence they were working.

“It’s the nature of the beast,” said Martin Bachmann, a professor and immunologist at the Jenner Institute, which is affiliated with Oxford University. “I’m not sure you can get rid of the side effects — it’s really what you want."

读来令人动容。Oncologists are becoming immunologists.

 

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