作者最后的讨论，也提到了补充叶酸增加乳腺癌的发生和发展 （与此研究揭示的通路相关）。
ROS can cause oncogenic mutations and activate oncogenic pathways, raising the possibility that treatment with antioxidants could suppress the initiation or progression of some cancers28, 35. Antioxidants or antioxidant enzymes suppress cancer initiation in some contexts36, 37, 38 while increasing cancer initiation in other contexts15, 16, 17, 39. Increasing dietary antioxidants has generally not reduced cancer incidence in clinical trials40. Dietary supplementation with antioxidants actually increased incidence and death from lung and prostate cancer41, 42, 43. Dietary supplementation with folate promotes the development and progression of breast cancer44, 45. Our results suggest that antioxidants promote disease progression, at least in melanoma, by promoting metastasis.
