【新研究】雌激素受体(ER)阳性乳癌患者的TSR值较高,则预后更好.

【新研究】发表在BJC的一项研究分析了ER阳性(Estrogen receptor positive,雌激素受体阳性)乳癌的TSR(Tumour-Stroma Ratio,肿瘤--基质比)是否具有同样的预后价值，共118名女性及62名男性的肿瘤HE切片的TSR值。证实: 如果ER阳性乳癌的TSR值较高，则预后更好，与TNBC(Triple-Negative Breast Cancer,三阴性乳癌) 相反。

【注解】三阴性乳腺癌（TNBC）是指雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体（HER2）均阴性的一种特殊类型乳腺癌。约占所有乳腺癌的15%。
 

原文链接:
http://www.nature.com/bjc/journal/v110/n7/abs/bjc201469a.html

Abstract

Background:

A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.

Methods: 

TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.

Results:

Tumours with 49% stroma were associated with better survival in female (OS P=0.008, HR=0.2–0.7; RFS P=0.006, HR=0.1–0.6) and male breast cancer (OS P=0.005, HR=0.05–0.6; RFS P=0.01, HR=0.87–5.6), confirmed in multivariate analysis.

Conclusions: 

High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.

 
【图】你该知道的乳腺癌知识

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