芬兰学者报道，生育10次以上妇女的癌症风险与参照人群之间存在显著差异。这些妇女患乳癌、卵巢癌、子宫内膜癌和皮肤基底细胞癌等恶性疾病的风险将显著降低，但甲状腺癌、唇癌和子宫肉瘤风险显著上升。
来源: Cancer Risk in Women With 10 or More Deliveries
Högnäs, Emma; Kauppila, Antti MD, PhD; Pukkala, Eero PhD; Tapanainen, Juha S. MD, PhD
Abstract
OBJECTIVE: To determine cancer incidence among Finnish women with 10 or more deliveries.
METHODS: Finnish women with at least 10 childbirths before December 31, 2010 (n=4,967) were identified from the Finnish Population Register and followed for cancer incidence through the Finnish Cancer Registry to the end of 2010. Cancer risks in this cohort were expressed as ratios between observed and expected numbers of cases (standardized incidence ratios), both drawn from the Finnish Cancer Registry, with 95% confidence intervals (CIs).
RESULTS: Total cancer incidence was markedly lower than in the reference population (656 cases, standardized incidence ratio 0.76, 95% CI 0.73–0.79). There was clearly less breast (0.44, 0.35–0.53), ovarian (0.49, 0.28–0.80), endometrial (0.31, 0.17–0.44), and basal cell skin cancer (0.72, 0.60–0.85) than in the reference population. The incidence of thyroid cancer (2.33, 1.59–3.29), lip cancer (2.87, 1.05–6.24), and uterine sarcoma (3.41, 1.47–6.72) was markedly increased.
CONCLUSION: Women with 10 or more deliveries show a decreased overall cancer incidence as a result of decreased risks of cancers of the ovary, endometrium, and breast and basal cell carcinoma of the skin. The increased risks were observed in thyroid cancer and some rare cancer types.
LEVEL OF EVIDENCE: II
© 2014 by The American College of Obstetricians and Gynecologists.
