维生素D与HDL低和LDL高相关。很可能背后的原因是相同的：在太阳底下跑得少了？

来源: 吃与活 于 2018-11-28 09:52:43 [] [博客] [旧帖] [给我悄悄话] 本文已被阅读： 次 (34401 bytes)
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https://www.lipidjournal.com/article/S1933-2874(15)00384-0/fulltext

The pathophysiology for deficient 25(OH)D causing an atherogenic lipid profile is unclear. Inadequate dietary intake of vitamin D may reduce calcium absorption in the gastrointestinal system. Prior studies have shown that deficient dietary intake of calcium is associated with higher body weight and a more atherogenic lipid metabolism,53, 54 potentially due to increased lipid metabolism in the body or reduced intake of cholesterol in the gut. However, the observed association between 25(OH)D and dyslipidemia may be confounded by shared metabolic risk factors rather than a causal mechanism. Serum 25(OH)D has been shown to be decreased in obese patients, in whom sequestration of 25(OH)D in body fat reduces detectable 25(OH)D in the serum.55 This phenomenon results in an inverse association between BMI and 25(OH)D. Given that BMI is also associated with dyslipidemia, the presence of obesity may explain the observed association of 25(OH)D with dyslipidemia. Unfortunately, we did not have BMI available in our data set to adjust for this potentially confounding variable. There also appears to be an association between lipid-lowering medication usage and increases in 25(OH)D,56, 57 suggesting that the observed association between low 25(OH)D levels and dyslipidemia may be due to patients with lipid derangements not being on statin therapy.

Although vitamin D supplementation is inexpensive, widely available, and effective in raising serum 25(OH)D, clinical trials have yet to find any link between vitamin D supplementation and changes in lipid profile or reduced CVD mortality.15, 18, 58, 59, 60, 61 Mendelian randomization studies have used single nucleotide polymorphisms leading to variations in 25(OH)D to examine vitamin D's role in the development of an atherogenic lipid profile and CVD.49, 62, 63 These studies have shown evidence that single nucleotide polymorphisms causing a genetically increased RLP-C49 and BMI62 are associated with reduced 25(OH)D. This supports the notion that 25(OH)D may be a marker for overall health rather than an independent risk factor for CVD. As there is not currently any definitive evidence that vitamin D has a causal role in atherosclerotic CVD,21 the associations seen in observational studies may be due to confounding factors that impact both serum 25(OH)D and serum lipids

所有跟帖： 

• 谢谢健康大师 -ylsm- ♀ 给 ylsm 发送悄悄话 (137 bytes) () 11/28/2018 postreply 10:08:48

• 大师 -吃与活- ♂ 给 吃与活 发送悄悄话 吃与活 的博客首页 (149 bytes) () 11/28/2018 postreply 12:32:44

• 把自己仰视学习的，有巨大帮助的人发自内心称大师，真心感谢你们的无私分享奉献 -ylsm- ♀ 给 ylsm 发送悄悄话 (0 bytes) () 11/28/2018 postreply 12:49:16

• 我住在‘阳光州’，每天走路都在太阳底下呢～～～不过看到‘维生素D与HDL低和LDL高相关’，也许还是补点维D吧？ -山菊花- ♀ 给 山菊花 发送悄悄话 山菊花 的博客首页 (0 bytes) () 11/28/2018 postreply 10:59:11

• 有可能维生素D低是原因，也许也是个结果。 -吃与活- ♂ 给 吃与活 发送悄悄话 吃与活 的博客首页 (0 bytes) () 11/28/2018 postreply 12:59:24

• 嗯，我准备先去买点维生素D来吃 -山菊花- ♀ 给 山菊花 发送悄悄话 山菊花 的博客首页 (0 bytes) () 11/28/2018 postreply 14:02:41

• 我曾经有过与你相反的疑问， -阿明.- ♀ 给 阿明. 发送悄悄话 (218 bytes) () 11/28/2018 postreply 14:06:33

• 个人情况还真是千差万别啊～～～所以我不想随便吃药 -山菊花- ♀ 给 山菊花 发送悄悄话 山菊花 的博客首页 (0 bytes) () 11/28/2018 postreply 14:09:32

• 这仅仅是我唯一提出的“副作用”，其他副作用尚未发现，我已经 -阿明.- ♀ 给 阿明. 发送悄悄话 (50 bytes) () 11/28/2018 postreply 14:31:30

• 你还在吃藏红花没有? -甜酒甜- ♀ 给 甜酒甜 发送悄悄话 甜酒甜 的博客首页 (201 bytes) () 11/28/2018 postreply 11:05:38

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