Si WANG
J4-246, Organische Chemie, Universität Paderborn
Warburger Str. 100, 33098 Paderborn
Deutschland (Germany)
Tel: 0049-5251-602180
E-mail: wangsi68@yahoo.com
-----------------------------------------------------
CAREER OBJECTIVE
Organic Synthesis, (Marine) Natural Products chemistry, Medicinal Chemistry
QUALIFICATIONS
1.Synthesis techniques: (1) organic synthesis of pharmacologically active natural products. (2) semisynthesis of natural products (3) structural modification of natural products
2. Separation techniques: proficient in isolation of varieties of compounds with chromatography including CC, TLC, MPLC and HPLC.
3. Structure elucidation: good at elucidation of the complex compounds including their relative and absolute stereochemistry by interpretation of spectroscopic data (UV, IR, NMR, MS, CD, X-ray and ORD) and chemical methods
......
PROFESSIONAL EXPERIENCE
10/2002 - 11/2003
Visiting Scholar, Department of Organic Chemistry, University of Parderborn, Germany
• Total Syntheis of the antifungal marine natural product with spirobisnaphthalene skeleton: Palmarumycins CP1and CP2, and isolation of the metabolites from marine fungi, Rchex hakt 6321, and 6297 etc.
09/1999 - 07/2002
Ph. D in Peking Union Medical College
• Semisynthesis of goniopypyrone acetonide and Asymmetric synthesis of (-)-Ligustiphenol
• National Project 973 (Basically Key National Research Project)
Fast separation and identification for trace chemical constituents of traditional Chinese medicine, we use means including (1) HPLC-NMR technology (2) HPLC-MS technology (3) GC-MS technology.
• Studies on the Chemical Constituents from the Roots of Goniothalamus Cheliensis Hu, Uvaria Macrophylla and Broussonetia Kazinoki.
09/1996 - 07/1999
Master student, China Pharmaceutical University and Shandong Academy of Medical Science
• Studies on the Chemical Constituent from the Flowers of Castanea Mollissima Blume
07/1988 - 08/1996
Pharmacist, Yuexi Hospital, Anhui Province
• Duties include (1) make up prescriptions (2) guide patients to use medicine (3) control for the quality of pharmaceutical and biological products (4) present the reports on the plan of medicine administration.
EDUCATION
......
AWARDS
1. 2000-2001 excellent graduate student The first-rate scholarship, Peking Union Medical College
2. 3000m track and field. The 4th Sports Meeting of Shandong Academy of Medical Sciences
3 The First-rate Chinese Calligraphy Prize, The 2nd Calligraphy Match of Yuexi Hospital
REFERENCE
Prof. De-Quan Yu
Member of Chinese Academy of Engineering
Member of American Society of Pharmacognosy
Vice Editor-in-chief, Journal of Asian Natural Product Research
Institute of Materia Medica, Peking Union Medical College & Chinese
Academy of Medical Sciences (PUMC & CAMS), Beijing 100050 P. R. China
dquanyu@imm.ac.cn
Prof. Karsten Krohn
Organische Chemie
Universität Paderborn
Warburger Str. 100, 33098 Paderborn
Deutschland (Germany)
kk@chemie.uni-paderborn.de
Prof. Nikolaus Risch
Vice President of Universität Paderborn
Organische Chemie
Universität Paderborn
Warburger Str. 100, 33098 Paderborn
Deutschland (Germany)
nr@chemie.uni-paderborn.de
======================
PUBLICATIONS
articles in journals
-----------------------
1.Si Wang et al, Total Syntheis of the antifungal marine natural product with spirobisnaphthalene skeleton: Palmarumycins CP1and CP2(2003) J. Org. Chem. (in preparation).
2. Ulrich Flörke, Wahyudi Priyono Suwarso, Ratna Layla Gani, Karsten Krohn and Si Wang (2003) Dasypogalactone-methanol-water, Acta Cryst. E59, 0638-0640.
3. Si Wang, Ruo-Yun Chen, Shi-Shan Yu and De-Quan Yu (2003) Novel Seco-cyclohexenes from Uvaria macrophylla, Journal of Asian Natural Product Research 1, 17 - 23.
4. Si Wang, Pei-Cheng Zhang, Sheng-Jun Dai, Ruo-Yun Chen, Shi-Shan Yu and De-Quan Yu (2003) Study on the Chemical Constituents of Uvaria macrophylla and Goniothalamus Cheliensis, Acta Chimica Sinica 61(7), 1090-1096.
5. Si WANG, Ruo Yun CHEN, De Quan Yu, (2003) Two new active styryllactones from the Roots of Goniothalamus Cheliensis Hu, Chinese Chemical Letters 14(5), 487-488
6. Si Wang,Yan-Jun Zhang, Ruo-Yun Chen and De-Quan Yu (2002) Goniolactones A-F: Six New Styryllactione Derivatives from the Roots of Goniothalamus Cheliensis Hu, Journal of Natural Products, 65, 835-841
7. Si WANG, Xing-bao DING, Ya-fei CHEN and De-quan YU (2001) A Novel Alkaloid from the Flowers of Castanea Mollissima Blume, Journal of Asian Natural Product Research, 3, 89-93.
8. Pei Cheng ZHANG, Si WANG, Yan Wu, Ruo Yun CHEN, De Quan Yu (2001) Five New Diisoprenylated Flavonols from the Leaves of Broussonetia Kazinok,i Journal of Natural Products, 64,1206-1209
9. Si WANG, Pei Cheng ZHANG, Ruo Yun CHEN, De Quan Yu (2001) Two New Compounds from Goniothalamus Cheliensis Hu, Chinese. Chemical Letters. 12, 787-790.
10. WANG Si, ZHANG Pei-Cheng, CHEN Ruo-Yun, YU De-Quan (2001) Studies on the Chemical Constituents of the Roots of Goniothalamus Cheliensis Hu, Acta Chimica Sinica. 59(10), 1823-1826 .
11. Pei Cheng ZHANG, Si WANG, Ying Hong WANG, Ruo Yun CHEN, De Quan Yu (2001) A New Isoprenylated Flavonol from the Leaves of Broussonetia Kazinoki, Chinese Chemical Letters12, 141-142.
12. WANG Ming-Lei, DU Jiang, WANG Si, CHEN Ruo-Yun, YU De-Quan (2001) Application of NMR Methods to Determine the Absolute Stereochemistry of Natural Products, Chinese Journal of Organic Chemistry, 41, 341-349.
13. Si WANG, Pei Cheng ZHANG, Ruo Yun CHEN, Ying Hong WANG, Wen Yi HE, De Quan YU (2002) A Novel Dihrydroflavone from the Roots of Uvaria Macrophylla,.Chinese Chemical Letters 13(9), 857-858.
14. LANG Feng, LI Li-jun, ZEPER Abliz, WANG Si, YU De-quan, (2001) Study on the alkaloids of G. Cheliensis Hu by MS-MS and GC-MS, Journal of Instrumental Analysis 20, 45-46.
15. ZHANG Hailing, WANG Si, CHEN Ruoyun and YU Dequan, (2002) The Chemical Constituents from Uvaria macrophylla, Acta Pharm. Sin., 37(2), 124-127.
16. WANG Si, TANG Wen-Zhao, DING Xing-Bao, WANG Xiao-Jing, (2003) Study on the chemical constituents of the flowers from Castanea Mollissima Blume Chinese Herbal Medicine (Acepted).
17. Si Wang, Pei-Cheng Zhang, Sheng-Jun Dai, Ruo-Yun Chen, Shi-Shan Yu and De-Quan Yu (2003) Four New Compounds of the roots from Uvaria macrophylla, Journal of Asian Natural Product Research (Accepted).
Patents
----------
1.Ding Xing-Bao, Wang Si, Wang Xiao-Jing, Xie Nian-Yin, Zhong Yin, Zhuo Zhun-Xu, Wang Fu-Wen (2000) Active New Flavonol Glycosides from the Flowers of Castanea Mollissima Blume The Patent of People’s Republic of China, No. 00134137.5 (CGCN10024), date 6. 12, 2000.
books
------
1. Zhao Shou-Xun, Jiang Ji-Wu, Wang Si etc Member of chemistry-editoriing group, China Pharmaceutical University: (1998) .Dictionary of Traditional Chinese Medicine (Zhong Yao Ci Hai) Vol 4. Chinese Press of Medical Sciences.
J4-246, Organische Chemie, Universität Paderborn
Warburger Str. 100, 33098 Paderborn
Deutschland (Germany)
Tel: 0049-5251-602180
E-mail: wangsi68@yahoo.com
-----------------------------------------------------
CAREER OBJECTIVE
Organic Synthesis, (Marine) Natural Products chemistry, Medicinal Chemistry
QUALIFICATIONS
1.Synthesis techniques: (1) organic synthesis of pharmacologically active natural products. (2) semisynthesis of natural products (3) structural modification of natural products
2. Separation techniques: proficient in isolation of varieties of compounds with chromatography including CC, TLC, MPLC and HPLC.
3. Structure elucidation: good at elucidation of the complex compounds including their relative and absolute stereochemistry by interpretation of spectroscopic data (UV, IR, NMR, MS, CD, X-ray and ORD) and chemical methods
......
PROFESSIONAL EXPERIENCE
10/2002 - 11/2003
Visiting Scholar, Department of Organic Chemistry, University of Parderborn, Germany
• Total Syntheis of the antifungal marine natural product with spirobisnaphthalene skeleton: Palmarumycins CP1and CP2, and isolation of the metabolites from marine fungi, Rchex hakt 6321, and 6297 etc.
09/1999 - 07/2002
Ph. D in Peking Union Medical College
• Semisynthesis of goniopypyrone acetonide and Asymmetric synthesis of (-)-Ligustiphenol
• National Project 973 (Basically Key National Research Project)
Fast separation and identification for trace chemical constituents of traditional Chinese medicine, we use means including (1) HPLC-NMR technology (2) HPLC-MS technology (3) GC-MS technology.
• Studies on the Chemical Constituents from the Roots of Goniothalamus Cheliensis Hu, Uvaria Macrophylla and Broussonetia Kazinoki.
09/1996 - 07/1999
Master student, China Pharmaceutical University and Shandong Academy of Medical Science
• Studies on the Chemical Constituent from the Flowers of Castanea Mollissima Blume
07/1988 - 08/1996
Pharmacist, Yuexi Hospital, Anhui Province
• Duties include (1) make up prescriptions (2) guide patients to use medicine (3) control for the quality of pharmaceutical and biological products (4) present the reports on the plan of medicine administration.
EDUCATION
......
AWARDS
1. 2000-2001 excellent graduate student The first-rate scholarship, Peking Union Medical College
2. 3000m track and field. The 4th Sports Meeting of Shandong Academy of Medical Sciences
3 The First-rate Chinese Calligraphy Prize, The 2nd Calligraphy Match of Yuexi Hospital
REFERENCE
Prof. De-Quan Yu
Member of Chinese Academy of Engineering
Member of American Society of Pharmacognosy
Vice Editor-in-chief, Journal of Asian Natural Product Research
Institute of Materia Medica, Peking Union Medical College & Chinese
Academy of Medical Sciences (PUMC & CAMS), Beijing 100050 P. R. China
dquanyu@imm.ac.cn
Prof. Karsten Krohn
Organische Chemie
Universität Paderborn
Warburger Str. 100, 33098 Paderborn
Deutschland (Germany)
kk@chemie.uni-paderborn.de
Prof. Nikolaus Risch
Vice President of Universität Paderborn
Organische Chemie
Universität Paderborn
Warburger Str. 100, 33098 Paderborn
Deutschland (Germany)
nr@chemie.uni-paderborn.de
======================
PUBLICATIONS
articles in journals
-----------------------
1.Si Wang et al, Total Syntheis of the antifungal marine natural product with spirobisnaphthalene skeleton: Palmarumycins CP1and CP2(2003) J. Org. Chem. (in preparation).
2. Ulrich Flörke, Wahyudi Priyono Suwarso, Ratna Layla Gani, Karsten Krohn and Si Wang (2003) Dasypogalactone-methanol-water, Acta Cryst. E59, 0638-0640.
3. Si Wang, Ruo-Yun Chen, Shi-Shan Yu and De-Quan Yu (2003) Novel Seco-cyclohexenes from Uvaria macrophylla, Journal of Asian Natural Product Research 1, 17 - 23.
4. Si Wang, Pei-Cheng Zhang, Sheng-Jun Dai, Ruo-Yun Chen, Shi-Shan Yu and De-Quan Yu (2003) Study on the Chemical Constituents of Uvaria macrophylla and Goniothalamus Cheliensis, Acta Chimica Sinica 61(7), 1090-1096.
5. Si WANG, Ruo Yun CHEN, De Quan Yu, (2003) Two new active styryllactones from the Roots of Goniothalamus Cheliensis Hu, Chinese Chemical Letters 14(5), 487-488
6. Si Wang,Yan-Jun Zhang, Ruo-Yun Chen and De-Quan Yu (2002) Goniolactones A-F: Six New Styryllactione Derivatives from the Roots of Goniothalamus Cheliensis Hu, Journal of Natural Products, 65, 835-841
7. Si WANG, Xing-bao DING, Ya-fei CHEN and De-quan YU (2001) A Novel Alkaloid from the Flowers of Castanea Mollissima Blume, Journal of Asian Natural Product Research, 3, 89-93.
8. Pei Cheng ZHANG, Si WANG, Yan Wu, Ruo Yun CHEN, De Quan Yu (2001) Five New Diisoprenylated Flavonols from the Leaves of Broussonetia Kazinok,i Journal of Natural Products, 64,1206-1209
9. Si WANG, Pei Cheng ZHANG, Ruo Yun CHEN, De Quan Yu (2001) Two New Compounds from Goniothalamus Cheliensis Hu, Chinese. Chemical Letters. 12, 787-790.
10. WANG Si, ZHANG Pei-Cheng, CHEN Ruo-Yun, YU De-Quan (2001) Studies on the Chemical Constituents of the Roots of Goniothalamus Cheliensis Hu, Acta Chimica Sinica. 59(10), 1823-1826 .
11. Pei Cheng ZHANG, Si WANG, Ying Hong WANG, Ruo Yun CHEN, De Quan Yu (2001) A New Isoprenylated Flavonol from the Leaves of Broussonetia Kazinoki, Chinese Chemical Letters12, 141-142.
12. WANG Ming-Lei, DU Jiang, WANG Si, CHEN Ruo-Yun, YU De-Quan (2001) Application of NMR Methods to Determine the Absolute Stereochemistry of Natural Products, Chinese Journal of Organic Chemistry, 41, 341-349.
13. Si WANG, Pei Cheng ZHANG, Ruo Yun CHEN, Ying Hong WANG, Wen Yi HE, De Quan YU (2002) A Novel Dihrydroflavone from the Roots of Uvaria Macrophylla,.Chinese Chemical Letters 13(9), 857-858.
14. LANG Feng, LI Li-jun, ZEPER Abliz, WANG Si, YU De-quan, (2001) Study on the alkaloids of G. Cheliensis Hu by MS-MS and GC-MS, Journal of Instrumental Analysis 20, 45-46.
15. ZHANG Hailing, WANG Si, CHEN Ruoyun and YU Dequan, (2002) The Chemical Constituents from Uvaria macrophylla, Acta Pharm. Sin., 37(2), 124-127.
16. WANG Si, TANG Wen-Zhao, DING Xing-Bao, WANG Xiao-Jing, (2003) Study on the chemical constituents of the flowers from Castanea Mollissima Blume Chinese Herbal Medicine (Acepted).
17. Si Wang, Pei-Cheng Zhang, Sheng-Jun Dai, Ruo-Yun Chen, Shi-Shan Yu and De-Quan Yu (2003) Four New Compounds of the roots from Uvaria macrophylla, Journal of Asian Natural Product Research (Accepted).
Patents
----------
1.Ding Xing-Bao, Wang Si, Wang Xiao-Jing, Xie Nian-Yin, Zhong Yin, Zhuo Zhun-Xu, Wang Fu-Wen (2000) Active New Flavonol Glycosides from the Flowers of Castanea Mollissima Blume The Patent of People’s Republic of China, No. 00134137.5 (CGCN10024), date 6. 12, 2000.
books
------
1. Zhao Shou-Xun, Jiang Ji-Wu, Wang Si etc Member of chemistry-editoriing group, China Pharmaceutical University: (1998) .Dictionary of Traditional Chinese Medicine (Zhong Yao Ci Hai) Vol 4. Chinese Press of Medical Sciences.
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