最近招工的多起来了，贴几个广告

招工多了，看起来只找顶尽的人。

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PK/PD and drug metabolism Investigator
Our client is looking for an individual with experience in both in vivo and in vitro DMPK experiments as well as knowledge in kinetics. Must have good understanding of metabolic pathways and related enzymes. Also required is the operation of LC/MS and sample extraction and preparation.
Will be required to interpret nonclinical and preclinical data as well as design in vivo PK/PD studies. Those with demonstrated innovative research in these areas will have an advantage. Prior experience in regulatory writing is also an advantage.
Must have a PhD and a minimum of 4 years post-doctoral experience in the pharmaceutical or biotech industry. Also required are strong written and verbal communication skills and the ability to supervise and mentor junior staff. Must have experience working in project teams and contribute to compound selection.
US residents only.
Please send resume to [e-mail]

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Clinical Pharmacology Position--Title depending on experience--US

My client is in the Northeast US and is looking for a PhD with several years experience in PK/PD data analysis, clinical pharmacology, and working knowledge of WinNonLin and NONMEM. Experience working with large and small compounds is a plus, as is good knowledge in immunology as far as understanding antibodies and fusion proteins. Must have experience in analyzing physiologically based PK/PD data. Title dependent on experience. Contact broseberry@cartermackay for more information

submitted by [e-mail]

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Scientific Project Leader in DMPK (Modeling and Simulation)

Who we are:
At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become
one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity,
and on seeing each other's differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning
and growing - and is seeking people who have the same goals for themselves.
The headquarters in Basel is one of Roche's largest sites. It is home to the Corporate Executive Committee, the Pharmaceuticals
and Diagnostics Divisions and the global business functions. Roche Basel also covers the entire business chain
from research, development and production through to marketing. Over 8,000 people from more than 60 countries work at
the site.
The Position:
The mission of the Global Preclinical Modeling and Simulation group at F. Hoffmann-La Roche Ltd. is to predict
the behavior of compounds in the body and to describe, in a quantitative way, dose-concentration-effect relationships.
As part of the Preclinical group, our responsibilities cover a wide range: from supporting the drug discovery groups in their
efforts to find new drug candidates to ensuring optimal support for the development of the compounds in our portfolio. You
will be responsible for conducting modeling and simulation using mechanistically based pharmacokinetic/pharmacodynamic
(PK/PD) models and state-of-the-art computer techniques to support drug candidate selection and development. With your
strong expertise in the area of mechanistically based pharmacokinetics and advanced PK/PD methods, you will support
drug discovery and drug development projects. Your responsibilities will include the development of new methods
to address issues related to modeling and simulation. Publication and presentation of research findings is strongly encouraged.
Who you are:
You're someone who wants to influence your own development. You're looking for a company where you have the opportunity
to pursue your interests across functions and geographies, and where a job title is not considered the final definition of
who you are, but the starting point.
You have an advanced degree (PhD or equivalent) in biomedical science with emphasis on mathematical modeling preferably
in preclinical pharmacokinetics and pharmacology and you have good experience in a variety of PBPK and PK/PD modeling
software. You have at least 3 years of industry or equivalent experiences and gained professional experience in designing,
interpreting and reporting PBPK and PK/PD studies. You are fluent in English and ideally have a good command of a
second language, preferably German or French.
Job ID No.: 19142
Contact Line: Th. Lave, Phone: [phone] or [phone]
The next step is yours. To apply online today or learn about other exciting positions, please visit http://careers.roche.com

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Principal Scientist, Team Lead

The successful candidate will be responsible for conducting and reporting plant and animal bioconcentration and metabolism studies for product registration following regulatory testing/current GLPs, including the use of the Microsoft platform. Also responsible for monitoring regulatory and technical changes, along with their incorporation and providing significant input to the marketing of these services. Will lead a team of lab personnel as well as be in charge of performace reviews, time off, etc.

Requirements:

BS degree and 15 years comparable laboratory experience.
MS degree and 8 years of comparable laboratory experience.
Ph.D and 5 years of comparable laboratory experience.

Knowledge/experience desired:

Preferably prior experience in a CRO environment as well as working with C14 material. Product chemistry testing experience/E-fate also helpful.

US residents only.
If interested, send CV to [e-mail]

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Senior Scientist / Project Representative, in vivo Pharmacokinetics - Research DMPK

Excellent Opportunity; Location: Belgium.

You will join an established biopharmaceutical company, dedicated to the discovery, development and commercialisation of innovative pharmaceutical and biopharmaceutical products in the fields of CNS and immunology.

Based within the CNS Research Hub and reporting to the Senior Director of Research DMPK, you will be responsible for the provision of practical and strategic PK support to all CNS drug discovery projects. You will be the primary point of contact on all issues relating to PK, PK/PD and PB/PK and will work closely with CNS Pharmacology and Experimental Medicine on the design and optimisation of in vivo pharmacological and early clinical models.
As a senior member of the Research DMPK department, you will also take a leading role in the DMPK support to drug discovery project teams, defining the DMPK strategy, providing data interpretation and risk assessment and influencing project strategy.

Educated to MSc or PhD level, you will bring to the role several years pharmaceutical or biotechnology industry experience, gained within a Discovery DMPK environment. You will demonstrate a strong technical background in a range of in vivo and in-vitro DMPK methodologies including bioanalysis, and a successful track record of representing your department on project teams. A good knowledge of the application of PK, PK/PD and PB/PK tools in drug discovery is essential in this high profile role. As a proactive and flexible networker with strong project management and influencing skills, you will have the knowledge and personal presence to be recognised as an internal expert in PK and PK/PD.

To apply, please contact Giorgia Signoretto on [phone] or [e-mail]

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