《英国医学杂志》论文: 低碳水化合物摄入会提高中风和心梗风险

来源: TBz 于 2012-08-13 16:46:33 [档案] [博客] [旧帖] [给我悄悄话] 本文已被阅读：次 (6507 bytes)

低碳水化合物摄入会提高中风和心梗风险

现在女性流行用控制饮食中碳水化合物的方法减肥，即少吃甚至不吃主食。但往往控制碳水化合物摄取量的同时，蛋白质的摄取量会呈增加趋势。但是美国最新研究发现，在饮食中长期控制碳水化合物摄取量的同时，蛋白质的摄取量会呈增加趋势，结果造成心肌梗塞和脑卒中的风险升高。研究中低碳水化合物、高蛋白质的倾向最严重的一组女性，其心肌梗塞和脑卒中的发病风险与其他女性相比最高可达1.6倍。

美国哈佛大学等机构的研究人员在新一期《英国医学杂志》上发表论文说，研究小组在1991年至1992年间调查了约4.34万名30岁至49岁的瑞典女性的饮食习惯，之后跟踪她们心肌梗塞和脑卒中等疾病的发病情况。跟踪时间平均约16年。

针对1270例在此期间发病的病例，研究人员按照碳水化合物和蛋白质的摄取量分成10个等级进行分析。结果是碳水化合物的摄取量每下降1个等级，蛋白质的摄取量每上升1个等级，心肌梗塞和脑卒中的发病风险就增加4%。（来源：新华社）

Low carbohydrate-high protein diet and incidence of cardiovascular diseases in Swedish women: prospective cohort study

Objective To study the long term consequences of low carbohydrate diets, generally characterised by concomitant increases in protein intake, on cardiovascular health. Design Prospective cohort study. Setting Uppsala, Sweden. Participants From a random population sample, 43 396 Swedish women, aged 30-49 years at baseline, completed an extensive dietary questionnaire and were followed-up for an average of 15.7 years. Main outcome measures Association of incident cardiovascular diseases (ascertained by linkage with nationwide registries), overall and by diagnostic category, with decreasing carbohydrate intake (in tenths), increasing protein intake (in tenths), and an additive combination of these variables (low carbohydrate-high protein score, from 2 to 20), adjusted for intake of energy, intake of saturated and unsaturated fat, and several non-dietary variables. Results A one tenth decrease in carbohydrate intake or increase in protein intake or a 2 unit increase in the low carbohydrate-high protein score were all statistically significantly associated with increasing incidence of cardiovascular disease overall (n=1270)—incidence rate ratio estimates 1.04 (95% confidence interval 1.00 to 1.08), 1.04 (1.02 to 1.06), and 1.05 (1.02 to 1.08). No heterogeneity existed in the association of any of these scores with the five studied cardiovascular outcomes: ischaemic heart disease (n=703), ischaemic stroke (n=294), haemorrhagic stroke (n=70), subarachnoid haemorrhage (n=121), and peripheral arterial disease (n=82). Conclusions Low carbohydrate-high protein diets, used on a regular basis and without consideration of the nature of carbohydrates or the source of proteins, are associated with increased risk of cardiovascular disease.

作者：Lagiou, Pagona; Sandin, Sven; Lof, Marie; Trichopoulos, Dimitrios; Adami, Hans-Olov; Weiderpass, Elisabete
期刊名称： BMJ : British Medical Journal
期卷页： 第344卷第期 ~页
学科领域：医学科学 » 内分泌系统/代谢和营养支持 » 营养不良与营养支持

原文链接：http://www.bmj.com/content/344/bmj.e4026